Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking
Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking
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DOI：
10.1038/nn.2282
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发表时间：
2009-03-01
影响因子：
25
通讯作者：
Tronche, Francois
中科院分区：
文献类型：
--
作者：
Ambroggi, Frederic;Turiault, Marc;Tronche, Francois
糖皮质激素受体是一种普遍存在的转录因子，介导对环境挑战和压力的适应。选择性消融表达多巴胺受体1a的小鼠多巴胺感觉神经元的Nr3c1（糖皮质激素受体基因），而非多巴胺释放神经元的Nr3c1基因，显著降低了小鼠自我给药的动机、多巴胺细胞放电以及多巴胺感觉神经元对多巴胺细胞放电活性的控制。相比之下，焦虑不受影响，这表明糖皮质激素受体通过不同的神经元群改变了许多行为障碍。
The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations.