The search and prime hypothesis for growth cone turning
The search and prime hypothesis for growth cone turning
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DOI：
10.1002/bies.20154
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发表时间：
2005-01-01
期刊：
影响因子：
4
通讯作者：
Andersen, SSL
中科院分区：
文献类型：
--
作者：
Andersen, SSL
在轴突和树突的指导领域，现在有一个重要的积累的知识，细胞外信号分子如何激活其同源生长锥受体。关于随后的细胞内信号传导通路的激活和肌动蛋白重组，以及微管（MT）在生长锥转动过程中如何重组，我们知之甚少。我假设，动态MT是必需的，以催化生长锥转动所需的极化肌动蛋白组装，MT和肌动蛋白丝通过正反馈促进彼此的组装，MT稳定性进一步增强，通过形成膜相关的MT附着位点，这些MT稳定事件随后加速轴突/树突状轴的形成。(C)2004 Wiley Periodicals，Inc.
In the fields of axonal and dendritic guidance, there is now a significant accumulation of knowledge of how extracellular signaling molecules activate their cognate growth cone receptors. Relatively little is known about the subsequent activation of intracellular signaling pathways and actin reorganization, and very little is known about how microtubules (MTs) reorganize during growth cone turning. I hypothesize that dynamic MTs are required in order to catalyze the polarized actin assembly necessary for growth cone turning, that MTs and actin filaments promote each other's assembly through positive feedback, that MT stability is enhanced further through the formation of membrane-associated MT attachment sites, and that these MT stabilization events subsequently accelerate axonal/dendritic shaft formation. (C) 2004 Wiley Periodicals, Inc.