Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma.
Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma.
复制标题
血清 HMGB1 作为恶性胸膜间皮瘤的预后标志物。
DOI：
10.1186/1471-2407-13-205
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发表时间：
2013-04-24
期刊：
影响因子：
3.8
通讯作者：
Nakano T
中科院分区：
文献类型：
--
作者：
Tabata C;Shibata E;Tabata R;Kanemura S;Mikami K;Nogi Y;Masachika E;Nishizaki T;Nakano T
恶性胸膜间皮瘤（MPM）是一种起源于间皮瘤的侵袭性恶性肿瘤，对常规化疗和放疗反应有限。因此，早期诊断MPM是非常重要的。一些研究人员先前报道了高迁移率组框1 （HMGB1）与肺纤维化相关。MPM涉及间皮细胞的恶性转化，起源于类似于肺成纤维细胞的间充质细胞。在这里，我们调查了MPM患者的血清HMGB1水平，并将其与暴露于石棉而未发生MPM的人群进行了比较。采用ELISA法测定MPM细胞株HMGB1的产量。还检测了61例MPM患者和45例良性石棉相关疾病患者的血清HMGB1水平。4株MPM细胞株中有2株HMGB1浓度高于正常间皮细胞株Met-5A。我们证明，MPM患者的血清HMGB1水平明显高于暴露于石棉但未发生MPM的人群。血清HMGB1水平低于和高于假设临界值组的总生存率差异显著。我们的数据表明血清HMGB1浓度是MPM的一个有用的预后因素。
Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to conventional chemotherapy and radiotherapy. Therefore, diagnosing MPM early is very important. Some researchers have previously reported that high-mobility group box 1 (HMGB1) was correlated with pulmonary fibrosis. MPM involves the malignant transformation of mesothelial cells, which originate from mesenchymal cells similar to lung fibroblasts. Here, we investigated serum levels of HMGB1 in patients with MPM and compared them with those of a population that had been exposed to asbestos without developing MPM. HMGB1 production from MPM cell lines was measured using ELISA. Serum HMGB1 levels were also examined in 61 MPM patients and 45 individuals with benign asbestos-related diseases. HMGB1 concentrations of 2 out of 4 MPM cell lines were higher than that of normal mesothelial cell line, Met-5A. We demonstrated that patients with MPM had significantly higher serum levels of HMGB1 than the population who had been exposed to asbestos but had not developed MPM. The difference in overall survival between groups with serum HMGB1 levels that were lower and higher than assumed cut-off values was significant. Our data suggest that serum HMGB1 concentration is a useful prognostic factor for MPM.
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DOI：
10.1152/ajplung.00075.2007
发表时间：
2007-12-01
影响因子：
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作者：
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DOI：
10.1164/rccm.200712-1894oc
发表时间：
2008-10-15
影响因子：
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通讯作者：
Blalock, J. Edwin