Brain activation during fast driving in a driving simulator:: the role of the lateral prefrontal cortex
Brain activation during fast driving in a driving simulator:: the role of the lateral prefrontal cortex
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DOI：
10.1097/wnr.0b013e3283056521
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发表时间：
2008-07-16
期刊：
影响因子：
1.7
通讯作者：
Esslen, Michaela
中科院分区：
文献类型：
--
作者：
Jaencke, Lutz;Brunner, Beatrice;Esslen, Michaela
目前对现实情况下驾驶行为的认知控制的神经基础知之甚少，特别是驾驶员的超速行为。在这项研究中，参与者在高端驾驶模拟器中呈现的真实场景中驾驶。当参与者在不同条件下驾驶时，记录了a波段（8-13 Hz）的头皮记录脑电振荡和30个电极的蒙太奇：（i）过快（快速），（ii）以受控方式以安全速度（正确），和（iii）在测试交通条件的情况下不耐烦（不耐烦）。使用低分辨率电断层扫描估计a带激活的脑内来源。鉴于先前的研究已经表明额叶皮层的Bold反应与a波段功率之间存在很强的负相关性，我们使用或波段相关活动作为额叶激活的估计。统计分析显示，在快速驾驶时，右侧前额叶皮层（包括背外侧前额叶皮层）的a带相关活动（即神经元激活较少）更多。那些速度最快、表现出更大冒险行为的参与者在左前外侧前额叶皮层表现出更强的a相关活动（即神经元激活较少）。这些发现是在当前理论的背景下讨论的作用，侧前额叶皮层在控制冒险行为，任务切换，和多任务。NeuroReport 19：1127-1130（C）2008年Wolters Kluwer Health垂直栏Lippincott威廉姆斯& Wilkins。
Little is currently known about the neural underpinnings of the cognitive control of driving behavior in realistic situations and of the driver's speeding behavior in particular. In this study, participants drove in realistic scenarios presented in a high-end driving simulator. Scalp-recorded EEG oscillations in the a-band (8-13 Hz) with a 30-electrode montage were recorded while the participants drove under different conditions: (i) excessively fast (Fast), (ii) in a controlled manner at a safe speed (Correct), and (iii) impatiently in the context of testing traffic conditions (Impatient). Intracerebral sources of a-band activation were estimated using low resolution electrical tomography. Given that previous studies have shown a strong negative correlation between the Bold response in the frontal cortex and the a-band power, we used or-band-related activity as an estimation of frontal activation. Statistical analysis revealed more a-band-related activity (i.e. less neuronal activation) in the right lateral prefrontal cortex, including the dorsolateral prefrontal cortex, during fast driving. Those participants who speeded most and exhibited greater risk-taking behavior demonstrated stronger a-related activity (i.e. less neuronal activation) in the left anterior lateral prefrontal cortex. These findings are discussed in the context of current theories about the role of the lateral prefrontal cortex in controlling risk-taking behavior, task switching, and multitasking. NeuroReport 19:1127-1130 (C) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.