Dependence of the contractile activation of skinned cardiac cells on the sarcomere length
Dependence of the contractile activation of skinned cardiac cells on the sarcomere length
复制标题
带皮心肌细胞的收缩激活对肌节长度的依赖性
作者：
A. Fabiato;F. Fabiato
FRANK 1和Starling 2已经证明，随着心脏舒张容积从最佳值向任何方向改变，心脏产生的收缩压都会降低。这一定律已经被解释为细（肌动蛋白）和粗（肌球蛋白）细丝之间的横桥数量的变化，这些横桥根据滑动细丝理论在单个细胞中产生力。
FRANK1 and Starling2 have demonstrated that the systolic pressure developed by the heart decreased as its diastolic volume was altered in either direction from an optimum value. This law has been explained by variations of the number of cross bridges between the thin (actin) and the thick (myosin) filaments which generate force in individual cells3,4 in accordance with the sliding filament theory5.