Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly
Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly
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DOI：
10.1128/aem.01477-07
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发表时间：
2007-12-01
影响因子：
4.4
通讯作者：
Isolauri, Erika
中科院分区：
文献类型：
--
作者：
Collado, M. Carmen;Derrien, Muriel;Isolauri, Erika
对Akkermansia Muciniphila的16S rRNA基因进行荧光原位杂交和实时PCR分析，以确定其在人肠道中的存在。这些技术表明，粘膜曲霉样细菌是人类肠道的常见成员，其定植始于早期生命，并在一年内发展到成年人观察到的水平（10（8）/g。 ），但老年人减少（p <0.05）。
Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila-like bacterium is a common member of the human intestinal tract and that its colonization starts in early life and develops within a year to a level close to that observed in adults (10(8) cells/g) but decreases (P < 0.05) in the elderly.