Risk of breast cancer among white women following induced abortion
Risk of breast cancer among white women following induced abortion
复制标题
DOI：
10.1093/oxfordjournals.aje.a008938
复制
发表时间：
1996-08-15
影响因子：
5
通讯作者：
Gammon, M
中科院分区：
文献类型：
--
作者：
Daling, JR;Brinton, LA;Gammon, M
一些研究（但不是全部）表明，先前的人工流产可能会增加患乳腺癌的风险。如果存在这种风险，则可能因堕胎发生的怀孕持续时间或妇女当时的年龄或胎次而异。作者在45岁以下的白人女性中进行了一项乳腺癌病例对照研究，以解决与人工流产有关的乳腺癌风险问题，目的是确定风险可能特别增加的妇女亚组。从1990年5月1日到1992年12月31日，在美国的三个地理区域（乔治亚州的亚特兰大；华盛顿州的西雅图/普吉特海湾；新泽西州中部的五个县）被诊断为乳腺癌的白人妇女（n=1,302）被采访了她们的生殖史，包括人工流产的发生。通过随机拨号从对照组女性中获得了类似的信息。使用Logistic回归分析来估计与人工流产史相关的乳腺癌相对风险，控制其他乳腺癌危险因素的潜在混杂影响。在至少怀孕一次的妇女中，有人工流产史的妇女患乳腺癌的风险比没有人工流产史的妇女高20%（95%置信区间为1.0-1.5）。这一风险的小幅增加随着堕胎次数或妇女目前的年龄变化不大。这种关联主要存在于妊娠9周前流产的未生育妇女中（估计相对危险度=2.0,95%可信区间为1.2-3.3）。在产妇中，与人工流产相关的乳腺癌风险没有增加。这些数据支持了一个假设，即在育龄的年轻女性中，有人工流产史的女性患乳腺癌的风险可能会小幅增加。然而，这项研究和其他研究的数据目前不允许因果解释；这些研究的总体结果也没有表明有一个妇女亚群与人工流产相关的相对风险异常高。
Some studies (but not all) have suggested that there may be an increase in the risk of breast cancer associated with a prior induced abortion. The risk, if present, may vary according to the duration of the pregnancy in which the abortion occurred, or to a woman's age or parity at that time. The authors conducted a case-control study of breast cancer in white women under age 45 years to address the question of breast cancer risk in relation to induced abortion, with the intention of identifying subgroups of women who might be at particularly increased risk. White women who were diagnosed with breast cancer (n=1,302) from May 1, 1990, through December 31, 1992, in three geographic regions of the United States (Atlanta, Georgia; Seattle/Puget Sound, Washington; and five counties in central New Jersey) were interviewed about their reproductive histories, including the occurrence of induced abortion. Similar information was obtained from control women identified through random digit dialing. Logistic regression analysis was used to estimate the relative risk of breast cancer associated with a history of induced abortion, controlling for the potentially confounding influence of other breast cancer risk factors, Among women who had been pregnant at least once, the risk of breast cancer in those with a prior induced abortion was 20% higher than that in women with no history of abortion (95% confidence interval 1.0-1.5). This small increase in risk varied little according to number of abortions or a woman's current age. The association was present primarily among nulliparous women whose abortions occurred prior to 9 weeks' gestation (estimated relative risk=2.0, 95% confidence interval 1.2-3.3). There was no excess risk of breast cancer associated with induced abortion among parous women. These data support the hypothesis that there may be a small increase in the risk of breast cancer related to a history of induced abortion among young women of reproductive age. However, the data from this study and others do not permit a causal interpretation at this time; neither do the collective results of the studies suggest that there is a subgroup of women in whom the relative risk associated with induced abortion is unusually high.