Gender differences in the developmental trajectories of multiple substance use and the effect of nicotine and marijuana use on heavy drinking in a high-risk sample
Gender differences in the developmental trajectories of multiple substance use and the effect of nicotine and marijuana use on heavy drinking in a high-risk sample
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DOI：
10.1016/j.addbeh.2015.06.015
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发表时间：
2015-11-01
影响因子：
4.4
通讯作者：
Zimmerman, Marc A.
中科院分区：
文献类型：
--
作者：
Buu, Anne;Dabrowska, Agata;Zimmerman, Marc A.
背景：在年轻人中，大量饮酒与尼古丁和大麻的使用高度共病。然而，我们对尼古丁和大麻使用（包括发病时间和数量/频率）对大量饮酒的纵向影响以及影响是否因性别而异的了解非常有限。本研究的目的是表征性别特异性的发展轨迹的多种物质的使用，并研究性别差异的尼古丁和大麻的使用对大量drinking.Methods的影响：我们进行了二次分析8波的数据，从850名高风险的青少年被招募为低GPA的九年级学生在经济上处于不利地位的学区在中西部，并每年随访到年轻的成年。在每一波中，通过自我报告问卷评估发作年龄和多种物质使用的数量/频率。结果：男性酗酒、尼古丁和大麻的使用水平从青少年期到初成年期呈持续增长趋势。另一方面，女性只是随着时间的推移逐渐增加尼古丁的使用，同时保持低水平的大量饮酒和大麻使用。控制酒精使用的早发状态，尼古丁使用和大麻使用的早发状态都增加了酗酒的额外风险;晚发大麻使用者也比非大麻使用者酗酒的风险更高。控制物质使用开始状态，更高的尼古丁和大麻使用量/频率都有助于更多地参与大量饮酒。我们还发现，尼古丁的使用量对大量饮酒的影响是更大的males.Conclusions：我们的研究表明，纵向影响的发病时间和数量/频率的尼古丁和大麻的使用大量饮酒。性别差异的Oar分析还确定了女性青年尼古丁使用和男性青年尼古丁和酒精的共同使用是未来预防和干预工作的两个重要领域。(C)2015爱思唯尔有限公司版权所有。
Background: Heavy drinking is highly comorbid with nicotine and marijuana use among young adults. Yet, our knowledge about the longitudinal effects of nicotine and marijuana use (including onset timing and quantity/frequency) on heavy drinking and whether the effects vary by gender is very limited. This study aims to characterize gender-specific developmental trajectories of multiple substance use and to examine gender differences in the effects of nicotine and marijuana use on heavy drinking.Methods: We conducted secondary analysis on 8 waves of data from 850 high-risk youth who were recruited as ninth graders with low GPA in an economically disadvantaged school district in the Midwest and were followed up annually to young adulthood. Onset ages and quantity/frequency of multiple substance use were assessed by a self-report questionnaire at each wave. The time-varying effect model and linear mixed model were adopted for statistical analysis.Results: Males' levels of heavy drinking, nicotine use, and marijuana use tended to grow persistently from adolescence to emerging adulthood. Females, on the other hand, only gradually increased their nicotine use across time while maintaining low levels of heavy drinking and marijuana use. Controlling for the early onset status of alcohol use, early onset statuses of nicotine use and marijuana use both added additional risk for heavy drinking; late onset marijuana users were also at higher risk for heavy drinking than nonusers of marijuana. Controlling for substance use onset statuses, higher quantity/frequency of nicotine and marijuana use both contributed to more involvement in heavy drinking. We also found that the effect of nicotine use quantity on heavy drinking was greater among males.Conclusions: Our study demonstrates the longitudinal effects of onset timing and quantity/frequency of nicotine and marijuana use on heavy drinking. Oar analysis of gender differences also identifies female youth's nicotine use and male youth's co-use of nicotine and alcohol as two important areas for future prevention and intervention work. (C) 2015 Elsevier Ltd. All rights reserved.