Cortical reorganization in patients with high frequency cochlear hearing loss
Cortical reorganization in patients with high frequency cochlear hearing loss
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DOI：
10.1016/s0378-5955(01)00282-9
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发表时间：
2001-08-01
期刊：
影响因子：
2.8
通讯作者：
Pantev, C
中科院分区：
文献类型：
--
作者：
Dietrich, V;Nieschalk, M;Pantev, C
动物研究表明，听觉皮质中的强直性表征在成年生物体中不是静态固定的，而是在去传入后可以改变的。本研究通过脑磁图测量的方法，研究高频耳蜗性耳聋患者听皮层的可塑性。数据显示，大脑皮层映射图可以重组，使得被剥夺了通常最敏感的传入输入的皮质神经元现在对接近部分听力损失频率范围的音调频率做出反应。这些结果提示，成人耳蜗性损伤所致的去传入可能导致听皮质结构的功能重组。(C)2001 Elsevier Science B.V.保留所有权利。
Animal research has shown that tonotopic representation in the auditory cortex is not statically fixed in the adult organism but can be altered after deafferentation. The present study examines the plasticity of the human auditory cortex in patients with high frequency cochlear hearing loss by means of magnetoencephalographic measurements. The data show that the cortical map can reorganize such that cortical neurons deprived of their usual most sensitive afferent input now respond to tone frequencies adjacent to the frequency range of the partial hearing loss. The results suggest that deafferentation due to cochlear damage in adults may lead to functional reorganization of auditory cortical structures. (C) 2001 Elsevier Science B.V. All rights reserved.