DISTRIBUTION OF NONTELOMERIC SITES OF THE (TTAGGG)N TELOMERIC SEQUENCE IN VERTEBRATE CHROMOSOMES
DISTRIBUTION OF NONTELOMERIC SITES OF THE (TTAGGG)N TELOMERIC SEQUENCE IN VERTEBRATE CHROMOSOMES
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DOI：
10.1007/bf01737283
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发表时间：
1990-04-01
期刊：
影响因子：
1.6
通讯作者：
MOYZIS, RK
中科院分区：
文献类型：
--
作者：
MEYNE, J;BAKER, RJ;MOYZIS, RK
确定了 100 种脊椎动物的 (TTAGGG)n 端粒重复非端粒位点的染色体内分布。该序列最常见的非端粒位置是在染色体的中心周区域。多种物种的组成型异染色质区域内存在相对大量的该序列。我们讨论了 (TTAGGG)n 序列的非端粒分布与核型进化过程之间可能的关系，在此期间这些位点可能提供潜在的新端粒。
The intrachromosomal distribution of non-telomeric sites of the (TTAGGG)n telomeric repeat was determined for 100 vertebrate species. The most common non-telomeric location of this sequence was in the pericentric regions of chromosomes. A variety of species showed relatively large amounts of this sequence present within regions of constitutive heterochromatin. We discuss possible relationships between the non-telomeric distribution of the (TTAGGG)n sequence and the process of karyotype evolution, during which these sites may provide potential new telomeres.