The PTX family of homeodomain transcription factors during pituitary developments
The PTX family of homeodomain transcription factors during pituitary developments
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DOI：
10.1016/s0303-7207(98)00026-4
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发表时间：
1998-05-25
影响因子：
4.1
通讯作者：
Tremblay, JJ
中科院分区：
文献类型：
--
作者：
Drouin, J;Lamolet, B;Tremblay, JJ
最近发现了一个与bicoid相关的同源结构域因子亚家族，其参与垂体特异性基因的转录。我们分离出这个家庭的第一个成员，Ptx1（垂体同源框1），通过其DNA结合特性，而第二个相关基因，Ptx2（RIEG），被确定为Rieger综合征的致病基因的位置克隆。Ptx作用于其靶基因的机制以及其在发育过程中的作用进行了综述，特别强调其在垂体功能中的作用。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
A subfamily of bicoid-related homeodomain factors was recently discovered through its involvement in transcription of pituitary-specific genes. We isolated the first member of this family, Ptx1 (pituitary homeobox 1), through its DNA binding properties whereas a second related gene, Ptx2 (RIEG), was identified by positional cloning as the causative gene for Rieger's syndrome. The mechanisms of Ptx action on its target genes as well as its putative roles during development are reviewed with particular emphasis on its role in pituitary function. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.