Evaluation of a Novel Cystoscopic Compatible Cryocatheter for the Treatment of Bladder Cancer
Evaluation of a Novel Cystoscopic Compatible Cryocatheter for the Treatment of Bladder Cancer
复制标题
DOI：
10.3233/blc-200321
复制
发表时间：
2020-01-01
期刊：
影响因子：
1.1
通讯作者：
Baust, John G.
中科院分区：
文献类型：
--
作者：
Baust, John M.;Robilotto, Anthony;Baust, John G.
背景：随着冷冻消融治疗非转移性癌症的接受度不断提高，新的冷冻外科技术和方法已经打开了大门。在泌尿生殖系统肿瘤领域，冷冻外科治疗膀胱癌在很大程度上仍处于研究阶段。目前的治疗方法是使用经皮针或经尿道冷冻球或喷雾器，虽然结果令人振奋，但每种技术都仅限于特定类型和阶段的癌症。目的：本研究评估了一种新的、自给自足的经尿道冷冻治疗仪，冻伤-BC，以评估其治疗膀胱癌的潜力。方法：通过热量测量、等温分析、体外三维组织工程模型(TEMS)和在体猪实验，评估热特性和消融能力。结果：等温评估显示表面温度在9秒内低于-20℃。体外TEMS研究表明，膀胱壁的全厚度消融可达到30秒。结论：这些研究表明，冻伤-BC冷冻仪作为膀胱癌的一种治疗选择具有潜力。虽然是初步的，但这些研究的结果是令人鼓舞的，并支持继续调查冻伤-BC冷冻仪作为下一代微创冷冻消融技术的潜力。
BACKGROUND: As the acceptance of cryoablative therapies for the treatment of non-metastatic cancers continues to grow, avenues for novel cryosurgical technologies and approaches have opened. Within the field of genitourinary tumors, cryosurgical treatments of bladder cancers remain largely investigational. Current modalities employ percutaneous needles or transurethral cryoballoons or sprays, and while results have been promising, each technology is limited to specific types and stages of cancers.OBJECTIVE: This study evaluated a new, self-contained transurethral cryocatheter, FrostBite-BC, for its potential to treat bladder cancer.METHODS: Thermal characteristics and ablative capacity were assessed using calorimetry, isothermal analyses, in vitro 3-dimensional tissue engineered models (TEMs), and a pilot in vivo porcine study.RESULTS: Isotherm assessment revealed surface temperatures below -20 degrees C within 9 sec. In vitro TEMs studies demonstrated attainment of = 30 sec full thickness ablation of the bladder wall.CONCLUSIONS: These studies demonstrate the potential of the FrostBite-BC cryocatheter as a treatment option for bladder cancer. Although preliminary, the outcomes of these studies were encouraging, and support the continued investigation into the potential of the FrostBite-BC cryocatheter as a next generation, minimally invasive cryoablative technology.