T‐Cell Proliferation and Expression of MHC Class II Antigens
T‐Cell Proliferation and Expression of MHC Class II Antigens
复制标题
T 细胞增殖和 MHC II 类抗原的表达
DOI：
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发表时间：
1984
影响因子：
3.7
通讯作者：
C. M. Steel
中科院分区：
文献类型：
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作者：
G. Brown;L. Walker;N. Ling;P. Richardson;G. Johnson;K. Guy;C. M. Steel
Two monoclonal antibodies to major histocompatibility complex (MHC) class II antigens, which in combination identify β chains encoded by the SB and DR loci, were used to investigate which of these gene‐ products were expressed at the cell surface of unstimulated T cells and at various stages of mitogen‐induced T‐cell maturation. In tests on blood lymphocytes from healthy donors 12% of Tcells expressed class II antigens, but only SB antigens were expressed. During activation of T lymphocytes, SB‐coded antigens were expressed before DR antigens, and the kinetics of SB expression correlated with the proliferative response of T cells. These results and consideration of recent reports from other laboratories lead us to suggest that 58‐coded class II antigens play a role in T‐cell proliferation.
