Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging.
Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging.
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DOI：
10.1111/jgs.13609
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发表时间：
2015-09
影响因子：
6.3
通讯作者：
Agrawal Y
中科院分区：
文献类型：
--
作者：
Bigelow RT;Semenov YR;Trevino C;Ferrucci L;Resnick SM;Simonsick EM;Xue QL;Agrawal Y
探讨与衰老相关的前庭功能丧失与年龄相关性视觉空间功能下降的关系。前瞻性队列研究中的横断面分析。巴尔的摩老龄化纵向研究（BLSA）。居住在社区的BLSA参与者，平均年龄为72岁（范围26-91）（N = 183）。使用前庭诱发肌生成电位测量前庭功能。视觉空间认知测试包括卡片旋转、普渡钉板、本顿视觉保持测试和轨迹测试A和b部分。执行功能、记忆和注意力的测试也被考虑在内。参与者接受了前庭和认知功能测试。在多元线性回归分析中，前庭功能较差与Card rotation （P = 0.001）、Purdue Pegboard （P = 0.005）、Benton视觉保留测试（P = 0.008）和trail making Test Part B （P = 0.04）的较差表现相关。执行功能和言语记忆测试的表现与前庭功能无显著相关性。探索性因素分析在接受所有认知测试的参与者亚组中确定了三种潜在的认知能力：视觉空间能力、言语记忆、工作记忆和注意力。前庭功能丧失与较低的视觉空间、工作记忆和注意因素得分显著相关。前庭功能和视觉空间能力测试之间的显著一致性关联在社区居住的成年人样本中被观察到。视觉空间技能受损通常是痴呆症和阿尔茨海默病的最初迹象之一。需要进一步的纵向研究来评估前庭功能与视觉空间能力之间是否存在因果关系。
To investigate the relationship between vestibular loss associated with aging and age-related decline in visuospatial function. Cross-sectional analysis within a prospective cohort study. Baltimore Longitudinal Study of Aging (BLSA). Community-dwelling BLSA participants with a mean age of 72 (range 26–91) (N = 183). Vestibular function was measured using vestibular-evoked myogenic potentials. Visuospatial cognitive tests included Card Rotations, Purdue Pegboard, Benton Visual Retention Test, and Trail-Making Test Parts A and B. Tests of executive function, memory, and attention were also considered. Participants underwent vestibular and cognitive function testing. In multiple linear regression analyses, poorer vestibular function was associated with poorer performance on Card Rotations (P = .001), Purdue Pegboard (P = .005), Benton Visual Retention Test (P = 0.008), and Trail-Making Test Part B (P = .04). Performance on tests of executive function and verbal memory were not significantly associated with vestibular function. Exploratory factor analyses in a subgroup of participants who underwent all cognitive tests identified three latent cognitive abilities: visuospatial ability, verbal memory, and working memory and attention. Vestibular loss was significantly associated with lower visuospatial and working memory and attention factor scores. Significant consistent associations between vestibular function and tests of visuospatial ability were observed in a sample of community-dwelling adults. Impairment in visuospatial skills is often one of the first signs of dementia and Alzheimer’s disease. Further longitudinal studies are needed to evaluate whether the relationship between vestibular function and visuospatial ability is causal.