Chronic obstructive pulmonary disease: capillarity and fiber-type characteristics of skeletal muscle.
Chronic obstructive pulmonary disease: capillarity and fiber-type characteristics of skeletal muscle.
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DOI：
10.1097/00008483-199811000-00005
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发表时间：
1998-11-01
期刊：
影响因子：
--
通讯作者：
Simard, C
中科院分区：
文献类型：
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作者：
Jobin, J;Maltais, F;Simard, C
背景技术背景：目的：比较慢性阻塞性肺疾病（COPD）患者和健康人股外侧肌毛细血管和肌纤维类型的比例（8例COPD：61.0 +/- 1.8岁[平均值+/- SEM]; 1秒用力呼气量42.0 +/- 2.1%预测值; 7例N：年龄54.0 +/- 1.1）。受试者接受了对麦角环素的极限最大运动试验。股外侧肌经皮活检后，切片切8至10微米厚，用Andersen方法染色毛细血管和Stevens方法染色纤维typing.Results：COPD患者与健康受试者相比，峰值耗氧量降低（1.2 +/- 0.1 vs 3.0 +/- 0.2 L/min）。COPD患者每平方毫米毛细血管数低于健康受试者（92.6 ± 16.1和213.3 ± 33.5，P < 0.001）; COPD组Ⅰ型纤维占43.5 ± 5.5%，Ⅱ型纤维占56.5 ± 5.5%，健康对照组Ⅰ型纤维占56.7 ± 3.4%，Ⅱ型纤维占43.2 ± 3.4%（P < 0.05）。此外，COPD患者的毛细血管/纤维比率为0.83 ± 0.05，而健康人为1.56 ± 0.10（P < 0.001）。结论：正如预期的那样，COPD患者表现出运动能力下降。肌肉分析结果表明，COPD患者的II型纤维的比例更大，毛细血管/纤维比正常人低得多。我们的结论是，慢性阻塞性肺疾病的不利影响纤维类型和下肢毛细血管化。这可能部分是由这些患者的失调引起的。
BACKGROUND: The purpose of this investigation was to compare capillarity and fiber type proportions of the vastus lateralis muscle between patients with chronic obstructive pulmonary disease (COPD) and healthy subjects.METHODS: Fifteen male subjects were included in the study (8 COPD: 61.0 +/- 1.8 years [mean +/- SEM]; forced expiratory volume in 1 second 42.0 +/- 2.1% predicted; 7 N: age 54.0 +/- 1.1). Subjects were submitted to a symptom-limited maximal exercise test on ergocycle. After a transcutaneous biopsy of the vastus lateralis muscle, sections were cut 8 to 10 microns thick and stained with the Andersen method for capillarity and Stevens method for fiber typing.RESULTS: Patients with COPD had a decrease in peak oxygen consumption compared with healthy subjects (1.2 +/- 0.1 versus 3.0 +/- 0.2 L/min). Number of capillaries per square millimeter was lower in patients with COPD versus healthy subjects (92.6 +/- 16.1 and 213.3 +/- 33.5, P < 0.001); percentages of fiber types were 43.5 +/- 5.5% type I, 56.5 +/- 5.5% type II in COPD, and 56.7 +/- 3.4% type I, 43.2 +/- 3.4% type II in healthy subjects (P < 0.05). In addition, capillaries/fiber ratio was 0.83 +/- 0.05 in COPD, and 1.56 +/- 0.10 in healthy subjects (P < 0.001).CONCLUSION: As expected, patients with COPD showed a decrease in exercise capacity. The muscle analysis results indicate that patients with COPD have a greater proportion of type II fibers and a much lower capillaries/fiber ratio than normal subjects. We conclude that COPD adversely affects fiber type and capillarization of the lower limbs. This could be partly caused by deconditioning in these patients.