Health status of adult long-term survivors of childhood cancer - A report from the childhood cancer survivor study
Health status of adult long-term survivors of childhood cancer - A report from the childhood cancer survivor study
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DOI：
10.1001/jama.290.12.1583
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发表时间：
2003-09-24
影响因子：
120.7
通讯作者：
Oeffinger, KC
中科院分区：
文献类型：
--
作者：
Hudson, MM;Mertens, AC;Oeffinger, KC
背景儿童期癌症的成年幸存者有可能出现医学和心理社会后遗症，这可能会对他们的健康状况产生不利影响。目的比较儿童期癌症的成年幸存者和兄弟姐妹的健康状况，并确定与不良结局相关的因素。设计、设置和参与者在9535名儿童期癌症幸存者研究的成年参与者中评估健康状况。一组在1970年至1986年间被诊断出患有儿童癌症的长期幸存者。随机选取2916名幸存者的兄弟姐妹作为对照组。主要结果测量六个健康状况领域进行评估：一般健康，心理健康，功能状态，活动限制，癌症相关的疼痛，和癌症相关的焦虑/恐惧。结果生存者报告不良一般健康状况的可能性显著高于对照组（比值比[OR]，2.5; 95%可信区间[Cl]，2.1-3.0; P
Context Adult survivors of childhood cancer are at risk for medical and psychosocial sequelae that may adversely affect their health status.Objectives To compare the health status of adult survivors of childhood cancer and siblings and to identify factors associated with adverse outcomes.Design, Setting, and Participants Health status was assessed in 9535 adult participants of the Childhood Cancer Survivor Study, a cohort of long-term survivors of childhood cancer who were diagnosed between 1970 and 1986. A randomly selected cohort of the survivors' siblings (n=2916) served as a comparison group.Main Outcome Measures Six health status domains were assessed: general health, mental health, functional status, activity limitations, cancer-related pain, and cancer-related anxiety/fears. The first 4 domains were assessed in the control group.Results Survivors were significantly more likely to report adverse general health (odds ratio [OR], 2.5; 95% confidence interval [Cl], 2.1-3.0; P