Spectral- and time-domain optical coherence tomography measurements of macular thickness in normal eyes and in eyes with diabetic macular edema
Spectral- and time-domain optical coherence tomography measurements of macular thickness in normal eyes and in eyes with diabetic macular edema
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DOI：
10.1038/eye.2011.293
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发表时间：
2012-03-01
期刊：
影响因子：
3.9
通讯作者：
Nguyen, Q. D.
中科院分区：
文献类型：
--
作者：
Ibrahim, M. A.;Sepah, Y. J.;Nguyen, Q. D.
目的应用时域和频域光学相干断层扫描（OCT）测量正常眼和糖尿病性黄斑水肿（DME）眼的黄斑厚度，并推导其转换公式。使用TD-OCT（Stratus OCT）和SD-OCT（SPECTRALIS HRA+OCT）采集黄斑中心1 mm和周围4个ETDRS子视野的视网膜厚度值。使用来自两个装置的中心（C）子场的测量来导出转换方程。该方程被用来预测SD-OCT值使用测量从TD-OCT。预测和实际SD-OCT measurements之间的协议assessed.Results在正常眼中，TD-OCT和SD-OCT测量的C子场之间的平均差异为76 μ m（CI 95 =74和77，分别）。推导出换算方程y=1.029x+72.49。在患有DME的眼睛中，使用该方程，SPECTRALIS预测值比实际测量值高5%，95%的预测值在实际测量值的9%以内。重新定位SD-OCT网格，以匹配TD-OCT上的位置，导致预测值落在7%的实际measurements.Conclusions实际厚度测量从SPECTRALIS和预测的厚度测量之间的百分比差异，使用转换方程，是在报告的限制内的重复性与DME的眼睛层云。我们的公式可能有助于将DME标准护理和临床试验中两种器械的OCT值关联起来。Eye（2012）26，454-462; doi：10.1038/eye.2011.293; 2011年12月2日在线发表
Purpose To report macular thickness values in normal eyes and eyes with diabetic macular edema (DME) using time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT), and to derive a conversion equation.Methods The index study was a prospective investigation conducted on 80 eyes from 40 normal subjects and 130 eyes from 118 patients with DME seen in our clinic. Retinal thickness values from the central 1mm of the macula and surrounding four ETDRS subfields were acquired using TD-OCT (Stratus OCT) and SD-OCT (SPECTRALIS HRA+OCT). Measurements of the central (C) subfield from both devices were used to derive a conversion equation. The equation was used to predict SD-OCT values using measurements from TD-OCT. Agreement between predicted and actual SD-OCT measurements was assessed.Results In normal eyes, the mean difference between TD-OCT and SD-OCT measurements of the C subfield was 76 mu m (CI95=74 and 77, respectively). The conversion equation, y=1.029x+72.49, was derived. In eyes with DME, using the equation, SPECTRALIS-predicted values were 5% higher than actual measurements, with 95% of predicted values falling within 9% of the actual measurements. Relocating SD-OCT grids to match the location on TD-OCT resulted in predicted values falling within 7% of actual measurements.Conclusions The percent difference between actual thickness measurements from SPECTRALIS and predicted thickness measurements, using the conversion equation, was within reported limits of repeatability of Stratus in eyes with DME. Our equation may help correlate OCT values from both devices in standard care and clinical trials for DME. Eye (2012) 26, 454-462; doi: 10.1038/eye.2011.293; published online 2 December 2011