Burn wound healing: present concepts, treatment strategies and future directions
Burn wound healing: present concepts, treatment strategies and future directions
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DOI：
10.12968/jowc.2017.26.1.5
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发表时间：
2017-01-01
影响因子：
1.9
通讯作者：
Moshiri, A.
中科院分区：
文献类型：
--
作者：
Oryan, A.;Alemzadeh, E.;Moshiri, A.
烧伤是最广泛的软组织损伤形式，偶尔会导致广泛和深度的伤口和死亡。烧伤会导致严重的精神和情绪困扰，因为过度的疤痕和皮肤收缩。烧伤的治疗一直是一个困难的医学问题，许多不同的方法被用来治疗这种局部伤害。生物膜是微生物的集合，可以延缓伤口愈合。抗菌药物的应用是预防和治疗烧伤创面感染的新方法之一，其作用于生物膜，预防创面感染。生物膜引发持续的、低度的炎症反应，损害上皮化和肉芽组织的形成。皮肤移植已被证明可以显著减少感染造成的死亡。然而，嫁接有相当大的局限性。这种损伤是持久的，许多患者长期遭受慢性疼痛。组织工程是一种新的方法，可以减少常规治疗的局限性，并产生免疫耐受的人工组织，从而为受损组织提供永久的解决方案；这些标准使其成为一种具有成本效益和可靠的治疗方式。为了克服目前烧伤创面愈合的局限性，了解有关愈合机制的最新发现是很重要的。在这里，作者讨论了烧伤创面愈合的最重要事件，并回顾了从体外到临床水平用于烧伤创面的最新治疗策略。最后，我们讨论了组织工程和再生医学在未来烧伤创面愈合、建模和重塑中的作用。
Burns are the most extensive forms of soft tissue injuries occasionally resulting in extensive and deep wounds and death. Burns can lead to severe mental and emotional distress, because of excessive scarring and skin contractures. Treatment of burns has always been a difficult medical problem and many different methods have been used to treat such injuries, locally. Biofilms are a collection of microorganisms that delay wound healing. One of the new methods of prevention and treatment of burn wound infections is application of antimicrobials, which act on biofilms and prevent the wound infection. Biofilm initiates a persistent, low-grade, inflammatory response, impairing both the epithelialisation and granulation tissue formation. Skin grafts have been shown to dramatically reduce deaths from infection. However, grafting has considerable limitations. Such injuries are long-lasting and many patients suffer from chronic pain for a long time. Tissue engineering is a new approach in reducing the limitations of conventional treatments and producing a supply of immunologically tolerant artificial tissue, leading to a permanent solution for damaged tissues; such criteria make it a costeffective and reliable treatment modality. To overcome the present limitations of burn wound healing, knowledge about the latest findings regarding healing mechanisms is important. Here the authors discuss the most important events regarding burn wound healing and review the latest treatment strategies that have been used for burn wounds from in vitro to clinical levels. Finally, we discuss the role of tissue engineering and regenerative medicine in the future of burn wound healing, modelling and remodelling.