Identification of diencephalic and brainstem cardiorespiratory areas activated during exercise
Identification of diencephalic and brainstem cardiorespiratory areas activated during exercise
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DOI：
10.1016/s0006-8993(96)00303-4
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发表时间：
1996-07-08
期刊：
影响因子：
2.9
通讯作者：
Waldrop, TG
中科院分区：
文献类型：
--
作者：
Iwamoto, GA;Wappel, SM;Waldrop, TG
本研究的目的是确定间脑和脑干活动的网站在运动（EX）在清醒的大鼠跑在跑步机上。运动期间活跃的大脑区域，与休息条件（非EX）相比，使用原癌基因c-fos的蛋白质产物的免疫细胞化学标记进行鉴定。在“防御区”或“下丘脑/下丘脑运动区”（包括下丘脑后部和外侧区）中观察到标记增加。在两个丘、导水管周围灰质、臂旁复合体和楔状核（“中脑运动区”）中发现EX标记增加。在n的内侧部分也发现EX标记增加。孤束和延髓头端和尾端腹外侧。引人注目的是，在EX期间没有标记与体感功能相关的丘脑区域的细胞，尽管背柱核也标记在对照组之上。因此，在运动过程中标记增加的区域与自主神经和躯体运动控制中涉及的大脑区域密切相关。这些来自清醒运动大鼠的结果支持先前在麻醉动物制备中获得的结果。
The purpose of this study was to identify diencephalic and brainstem sites active during exercise (EX) in conscious rats running on a treadmill. Brain areas active during exercise, compared to rest conditions (non-EX), were identified using immunocytochemical labelling of the protein product of the proto-oncogene c-fos. Increased labelling was observed in the 'defence area' or 'hypothalamic/subthalamic locomotor regions' including the posterior and lateral hypothalamic areas. Increased labelling with EX was found in both colliculi, the periaqueductal gray matter, the parabrachial complex and the cuneiform nucleus ('mesencephalic locomotor region'). Increased labelling with EX was also found in the medial portion of n. tractus solitarius, and both the rostral and caudal ventrolateral medulla. Conspicuous by an absence of labelling during EX were cells in thalamic areas associated with somatosensory function, although the dorsal column nuclei were also labelled above control. Thus, areas in which labelling was increased during exercise closely correlate with the brain areas which have been implicated in both autonomic and somatomotor control. These results from awake, exercising rats support those obtained previously in anesthetized animal preparations.