FATIGUE AND HEART-DISEASE - THE ASSOCIATION BETWEEN VITAL EXHAUSTION AND PAST, PRESENT AND FUTURE CORONARY HEART-DISEASE
FATIGUE AND HEART-DISEASE - THE ASSOCIATION BETWEEN VITAL EXHAUSTION AND PAST, PRESENT AND FUTURE CORONARY HEART-DISEASE
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DOI：
10.1016/0022-3999(89)90088-3
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发表时间：
1989-01-01
影响因子：
4.7
通讯作者：
MULDER, P
中科院分区：
文献类型：
--
作者：
APPELS, A;MULDER, P
为了研究生命衰竭与冠心病不同表现之间的关系，对3877名39-65岁男性进行了前瞻性研究。对这一群体的研究平均为期4.2年。通过马斯特里赫特量表评估生命力衰竭，一种以异常疲劳、沮丧或失败的感觉以及易怒增加为特征的精神状态。得分在上三分之一的受试者被标记为筋疲力尽，并与得分在下三分之一或中三分之一的受试者进行比较。筛选时与生命衰竭相关的心绞痛的年龄校正相对危险度为4.17（p < 0.01），筛选时不稳定型心绞痛的年龄校正相对危险度为17.21（p < 0.001）。除最年轻年龄组外（OR = 3.76; p = 0.05），未观察到生命力衰竭与既往心肌梗死之间存在相关性。筛选时无冠心病的受试者。随访期间心绞痛54例，非致死性心肌梗死38例，致死性心肌梗死21例。随访时心绞痛的年龄校正相对危险度为1.86（p < 0.03），非致命性心肌梗死的年龄校正相对危险度为2.28（p < 0.001）。未发现生命衰竭与致命事件之间存在关联。
In order to study the association between vital exhaustion and different manifestations of coronary heart disease, a prospective study was conducted among 3877 males, aged 39-65. This group was studied during a mean period of 4.2 years. Vital exhaustion, a mental state characterized by unusual fatigue, a feeling of being dejected or defeated, and increased irritability, were assessed by means of the Maastricht Questionnnaire. Subjects who scored in the upper third were labelled as exhausted and were compared with those who scored in the lower or middle third. The age-adjusted relative risk of angina pectoris at screening that was associated with vital exhaustion was 4.17 (p < 0.01); that of unstable angina pectoris at screening was 17.21 (p < 0.001). No association was observed between vital exhaustion and past myocardial infarction, except in the youngest age group (OR = 3.76; p = 0.05). Among the subjects free from coronary heart disease at screening. 54 cases of angina pectoris, 38 cases of non-fatal myocardial infarction, and 21 cases of fatal myocardial infarction were observed during follow-up. The age-adjusted relative risk of angina pectoris at follow-up was found to be 1.86 (p < 0.03) and that of non-fatal myocardial infarction was found to be 2.28 (p < 0.001). No association was found between vital exhaustion and fatal events.