Hypercytokinemia in Hemophagocytic Syndrome
Hypercytokinemia in Hemophagocytic Syndrome
复制标题
噬血细胞综合征中的高细胞因子血症
DOI：
10.1097/00043426-199302000-00012
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
S. Imashuku
中科院分区：
文献类型：
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作者：
F. Fujiwara;S. Hibi;S. Imashuku
目的探讨噬血细胞综合征（HPS）中细胞因子血症在其发病机制中的作用以及细胞因子血症是否具有预后价值。患者和方法：在29名儿童和3名成人的HPS急性期，测定了血清铁蛋白、干扰素（IFN）-γ、可溶性白细胞介素-2（IL-2）受体、IL-6和其他细胞因子的浓度。对恶性肿瘤相关性（MAHS; n = 17）和感染相关性噬血细胞综合征（IAHS; n = 15）以及存活和致死病例的比较数据进行评估。结果：HPS患者均存在高铁蛋白血症和高细胞因子血症。17例MAHS中的11例和15例IAHS中的3例是致命的（p < 0.05）。在MAHS和IAHS之间没有观察到细胞因子浓度的显著差异。结论：在细胞因子对患者预后的影响方面，认为血清IL-6浓度>300 ng/L和IFN-γ浓度>30 U/ml或可溶性IL-2受体（sIL-2 R）浓度> 10，000 U/ml反映HPS患者的预后不良。
Purpose The study was performed to clarify in the hemophagocytic syndrome (HPS) how cytokinemia plays a role in its pathogenesis and if cytokinemia is of prognostic value. Patients and Methods : Serum concentrations of ferritin, inteiferon (IFN)-γ, soluble interleukin-2 (IL-2) receptor, IL-6, and other cytokines were determined during the acute phase of the HPS in 29 children and three adults. Data comparing malignancy-associated (MAHS; n = 17) and infection-associated hemophagocytic syndrome (IAHS; n = 15) and those comparing surviving and fatal cases were assessed. Results : Hyperferritinemia and hypercytokinemia were present in all patients with HPS. Eleven of the 17 MAHS and three of the 15 IAHS cases were fatal (p < 0.05). No significant difference in cytokine concentrations was observed between MAHS and IAHS. Conclusions : In terms of cytokine effect on patient outcome, serum concentrations of IL-6 >300 ng/L and IFN-γ concentrations >30 U/ml or soluble IL-2 receptor (sIL-2R) concentrations >10,000 U/ml were considered to reflect a poor prognosis in HPS patients.