ROLE OF THYMUS-DEPENDENT IMMUNITY IN MYCOPLASMA-PULMONIS INFECTIONS OF MICE
ROLE OF THYMUS-DEPENDENT IMMUNITY IN MYCOPLASMA-PULMONIS INFECTIONS OF MICE
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DOI：
10.1099/00222615-5-3-327
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发表时间：
1972-01-01
影响因子：
3
通讯作者：
TAYLORRO.D
中科院分区：
文献类型：
--
作者：
DENNY, FW;ALLISON, AC;TAYLORRO.D
在正常小鼠和胸腺切除、X射线照射、抗淋巴细胞处理的小鼠中研究了肺支原体感染的发病机制。免疫抑制的小鼠比正常小鼠更容易被鼻腔途径感染，尽管支原体在缺陷动物的肺部繁殖的程度只略大一些。支原体从肺部扩散到其他器官，如大脑，在免疫缺陷的小鼠中发生得更频繁。细胞免疫在肺部病变的发生发展中起重要作用。因此，正常小鼠的肺表现出明显的细支气管周和血管周围淋巴细胞的袖带，但在免疫抑制的小鼠中这一现象并不明显，巨噬细胞的数量也较少。免疫荧光研究进一步证明了细胞介导的免疫机制在肺巨噬细胞中的重要作用。小鼠的肺病感染。讨论了这种机制可能的运作方式。
The pathogenesis ofMycoplasma pulmonisinfection was studied in normal mice and in thymectomised, X-irradiated, anti-lymphocyte-treated mice. The immunosuppressed mice were more readily infected by the intranasal route than were normal mice, although the mycoplasmas multiplied to only a slightly greater extent in the lungs of the deficient animals. Spread of mycoplasmas from the lungs to other organs, such as the brain, occurred more frequently in the immunologically deficient mice. Cell-mediated immunity appeared to be important in the development of the pulmonary lesions. Thus, the lungs of normal mice showed marked peribronchiolar and perivascular cuffing by lymphocytes, but this was much less prominent in the immunosuppressed mice and macrophages were also fewer in number.Immunofluorescence studies provided further evidence for the important role of cell-mediated immune mechanisms inM. pulmonisinfections in mice. The way in which such mechanisms may operate is discussed.