Relation of plasma norepinephrine and sympathetic traffic during hypotension in humans.
Relation of plasma norepinephrine and sympathetic traffic during hypotension in humans.
复制标题
人类低血压期间血浆去甲肾上腺素与交感神经交通的关系。
DOI：
10.1152/ajpregu.1990.258.4.r982
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Goldstein,DS
中科院分区：
文献类型：
--
作者：
Rea,RF;Eckberg,DL;Fritsch,JM;Goldstein,DS
我们比较了9名健康志愿者在硝普钠（NP）控制性降压期间和之后肘前静脉血浆去甲肾上腺素（NE）水平和腓神经肌肉交感神经活性（MSA）的变化。在NP期间，MSA以98.7%/min增加，在4 min达到基线的399 +/- 77%（SE）峰值，然后下降，因此在输注结束时MSA为基线的298 +/- 39%。NE以9.2%/min增加，在输注结束前14.5 min达到峰值，为基线的231 +/- 31%。接近NP结束时MSA和NE的百分比增加无显著差异。NE达峰时间比MSA达峰时间滞后近10分钟。这些结果表明，在交感神经流出增加期间，NE从神经效应器接头扩散和洗脱导致静脉引流中NE的延迟增加;百分比变化在长期稳定的轻度低血压期间，MSA和NE是相似的。研究结果提供了条件支持使用NE的变化，以表明交感神经交通的变化。
We compared changes in antecubital venous plasma levels of norepinephrine (NE) and peroneal nerve muscle sympathetic activity (MSA) during and after nitroprusside (NP)-induced hypotension in nine healthy volunteers. During NP, MSA increased at 98.7%/min, peaked at 4 min at 399 +/- 77% (SE) of base line, and then decreased, so that at the end of the infusion MSA was 298 +/- 39% of base line. NE increased at 9.2%/min and peaked at 14.5 min at 231 +/- 31% of base line just before the end of the infusion. Percent increases of MSA and NE near the end of NP were not significantly different. The time-to-peak NE lagged the time-to-peak MSA by nearly 10 min. These results suggest that during increases of sympathetic outflow diffusion and washout of NE from neuroeffector junctions result in delayed increases in NE in the venous drainage; percent changes in MSA and NE during prolonged stable mild hypotension are similar. The findings provide conditional support for the use of changes in NE to indicate changes in sympathetic traffic.