PATHOLOGIC-CHANGES IN PERIPHERAL AIRWAYS OF YOUNG CIGARETTE SMOKERS
PATHOLOGIC-CHANGES IN PERIPHERAL AIRWAYS OF YOUNG CIGARETTE SMOKERS
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DOI：
10.1056/nejm197410102911503
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发表时间：
1974-01-01
影响因子：
158.5
通讯作者：
RICE, DB
中科院分区：
文献类型：
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作者：
NIEWOEHNER, DE;KLEINERMAN, J;RICE, DB
系统地研究了来自非医院猝死人群的年轻吸烟者和年龄相当的对照组的肺部，以确定吸烟与周围气道病理变化之间的关系。观察到的特征性病变是呼吸性细支气管炎，伴有成团的色素肺泡巨噬细胞，在所有吸烟者的肺部都存在，但在非吸烟者中很少见到（p<0.002）。与对照组相比，吸烟者肺壁炎细胞和膜性细支气管脱落上皮虽小但明显增加（p<0.05）。我们假设这种呼吸性细支气管炎是向心性肺气肿的前兆，可能是在年轻吸烟者中观察到的细微功能异常的原因。（中华医学杂志，29 (1):755-758,1974）
The lungs of young smokers and controls of comparable age from a population of sudden non-hospital deaths were systematically studied to determine the relation between cigarette smoking and pathologic changes in peripheral airways. The characteristic lesion observed was a respiratory bronchiolitis associated with clusters of pigmented alveolar macrophages and was present in the lungs of all smokers studied but rarely seen in nonsmokers (p<0.002). The lungs of smokers also showed small but significant increases in mural inflammatory cells and denuded epithelium in the membranous bronchioles as compared to controls (p<0.05). We postulate that this respiratory bronchiolitis is a precursor of centriacinar emphysema and may be responsible for the subtle functional abnormalities observed in young smokers. (N Engl J Med 291: 755–758, 1974)