The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate
The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate
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DOI：
10.1038/s41590-021-01049-2
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发表时间：
2021-10-06
影响因子：
30.5
通讯作者：
Gibbons, Deena L.
中科院分区：
文献类型：
--
作者：
Gee, Sarah;Chandiramani, Manju;Gibbons, Deena L.
现在，许多婴儿的母亲在怀孕期间暴露于SARS-CoV-2。在这里，作者研究了这种暴露对人类新生儿免疫学的影响，尽管垂直传播的证据有限，但仍显示出免疫变化和新生儿细胞因子反应增加。尽管对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）进行了广泛的研究，但母体感染对新生儿的影响尚不清楚。为了调查这一点，我们的特点是新生儿的免疫学的母亲证实SARS-CoV-2感染在怀孕期间。在这里，我们表明，母亲SARS-CoV-2感染影响新生儿免疫系统。尽管B细胞、CD 4（+）T细胞和CD 8（+）T细胞的比例相似，但与恢复或未感染的母亲所生的新生儿相比，在近期或持续感染的母亲所生的新生儿中检测到自然杀伤细胞、V δ 2（+）γ δ T细胞和调节性T细胞的百分比增加。在近期或持续感染组的新生儿和母亲中，血浆细胞因子水平升高也很明显。与未感染母亲所生的新生儿相比，SARS-CoV-2暴露母亲所生的新生儿细胞因子功能增强。在大多数新生儿中，这种免疫印记是非特异性的，表明SARS-CoV-2的垂直传播是有限的，这一发现得到了新生儿中缺乏SARS-CoV-2特异性IgM的支持，尽管母亲IgG转移。
Many babies have now been born to mothers who were exposed to SARS-CoV-2 during their pregnancy. Here the authors look at the effect of this exposure on the immunology of human neonates, showing immune changes and increased neonatal cytokine responses despite limited evidence of vertical transmission.Despite extensive studies into severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the effect of maternal infection on the neonate is unclear. To investigate this, we characterized the immunology of neonates born to mothers with confirmed SARS-CoV-2 infection during pregnancy. Here we show that maternal SARS-CoV-2 infection affects the neonatal immune system. Despite similar proportions of B cells, CD4(+) T cells and CD8(+) T cells, increased percentages of natural killer cells, V delta 2(+) gamma delta T cells and regulatory T cells were detected in neonates born to mothers with recent or ongoing infection compared with those born to recovered or uninfected mothers. Increased plasma cytokine levels were also evident in neonates and mothers within the recent or ongoing infection group. Cytokine functionality was enhanced in neonates born to SARS-CoV-2-exposed mothers, compared to those born to uninfected mothers. In most neonates, this immune imprinting was nonspecific, suggesting vertical transmission of SARS-CoV-2 is limited, a finding supported by a lack of SARS-CoV-2-specific IgM in neonates despite maternal IgG transfer.