Oxygen affinity and acid-base status of human blood during exposure to hypoxia and carbon monoxide.
Oxygen affinity and acid-base status of human blood during exposure to hypoxia and carbon monoxide.
复制标题
暴露于缺氧和一氧化碳时人体血液的氧亲和力和酸碱状态。
DOI：
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发表时间：
1968
期刊：
影响因子：
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通讯作者：
K. Mellemgaard
中科院分区：
文献类型：
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作者：
R. Mulhausen;P. Astrup;K. Mellemgaard
8名高原低氧受试者氧合血红蛋白解离曲线右移，pH 7.40的半饱和氧分压由26.7~30.2 mm Hg平均变化。血红蛋白对氧的亲和力在缺氧后12小时内开始下降。这一变化在低压舱模拟高空的短时间曝光实验中得到了证实。在长时间的一氧化碳暴露中，氧解离曲线发生了预期的左移，但没有发现适应性的变化。对这些差异的生理意义进行了讨论。提示高原快速右移可能是一种生理调节。
In eight subjects exposed to hypoxia at high altitude the oxyhemoglobin dissociation curve was shifted to the right, the half saturation oxygen tension at pH 7.40 being changed from 26.7 to 30.2 mm Hg on the average. The decreased affinity of hemoglobin for oxygen appeared within 12 hours after exposure to hypoxia. The shift was confirmed in short exposure experiments using simulated high altitude in a low pressure chamber. At prolonged carbon monoxide exposure the expected shift of the oxygen dissociation curve to the left occurred, but no adaptive changes were found. The physiological implication of these differences are discussed. It is suggested that the rapid shift to the right at high altitude may be a physiological regulation.