Who is really in control of skin immunity under physiological circumstances – lymphocytes, dendritic cells or keratinocytes?
Who is really in control of skin immunity under physiological circumstances – lymphocytes, dendritic cells or keratinocytes?
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DOI：
10.1111/j.1600-0625.2006.00506_1.x
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发表时间：
2006-11
影响因子：
3.6
通讯作者：
R. Paus;J. Schröder;K. Reich;K. Kabashima;F. Liu;N. Romani;M. Metz;A. Kerstan;P. H. A. Lee-P.-H.-A.-L
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文献类型：
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作者：
R. Paus;J. Schröder;K. Reich;K. Kabashima;F. Liu;N. Romani;M. Metz;A. Kerstan;P. H. A. Lee-P.-H.-A.-L
摘要：我们对皮肤免疫戏剧性的看法正在不断发生变化。这些不仅反映了一般免疫学和皮肤生物学的范式转变，而且具有深远的临床意义，这需要皮肤病治疗的战略变化。在解决这一新的争议特征所提出的问题时，没有任何地方能比这一点更具有指导性和吸引力。因此，在T细胞和朗格汉斯细胞作为皮肤免疫舞台上的“主角”统治了很长一段时间后，低水平的角质形成细胞最近以先天性皮肤免疫系统的关键主角的身份惊人地亮相，该系统甚至可能控制获得性皮肤免疫反应。进一步增加了戏剧性的复杂性和紧张性，肥大细胞作为另一个演员进入了中心舞台，而表皮朗格汉斯细胞作为免疫耐受的主要介质意外地出现了。尊敬的读者们，希望您能欣赏由皮肤病专家提供的精彩场面，他们兼任“舞台经理”，将各自喜爱的演员推到了聚光灯下。你可以从一场好的表演中得到你所期望的一切--包括引诱你进入剧院并为你搭建舞台的导演的序曲，竞争的天后，最近发现的新人才，甚至在表演还在进行的时候评论家的摘要。当帷幕落下时，你将已经就如何回答这部剧的标题问题得出了你自己的独立结论-至少目前是…
Abstract: Our views of the skin immunity theatre are undergoing constant change. These not only reflect paradigm shifts in general immunology and skin biology, but also have profound clinical implications, which call for strategic changes in dermatological therapy. Nowhere can this be witnessed at a greater level of instructiveness and fascination than when addressing the question posed by this new Controversies feature. Thus, after a very long period of dominance by T cells and Langerhans cells as ‘lead actors’ on the skin immunity stage, the lowly keratinocyte has recently made an astounding theatrical appearance as a key protagonist of the innate skin immunity system, which may control even acquired skin immune responses. Further enhancing dramatic complexity and tension, the mast cell has entered as an additional actor claiming centre stage, and the epidermal Langerhans cell has slipped in a surprise appearance as the chief agent of immunotolerance. May you, esteemed reader, enjoy the spectacle offered here by selected immunodermatology authorities who double as ‘stage managers’ pushing their respective favourite actors into the limelight. You get everything you may expect from a good performance – complete with the impresario's overture that lures you into the theatre and sets the stage, competing divas, recently discovered new talents and even the critic's digest while the performance is still ongoing. By the time the curtain drops, you will have reached your own, independent conclusions on how to answer the title question of this play – at least for the time being…