Peptide Nanomaterials Designed from Natural Supramolecular Systems
Peptide Nanomaterials Designed from Natural Supramolecular Systems
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DOI：
10.1002/tcr.201800149
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发表时间：
2019-05-01
期刊：
影响因子：
6.6
通讯作者：
Matsuura, Kazunori
中科院分区：
文献类型：
--
作者：
Inaba, Hiroshi;Matsuura, Kazunori
天然的超分子组装具有独特的结构和功能特性，这些特性在进化过程中得到了优化。受这些自然系统的启发，以多肽、蛋白质和核酸为成分，开发了各种生物纳米材料。肽是一种有吸引力的构建模块，因为它们可以在保留原始结构和功能的同时分离和优化天然蛋白质组合的重要结构域。此外，肽亚基可以与外源分子如肽、蛋白质、核酸和金属纳米颗粒结合以产生高级功能。在这篇个人报告中，我们总结了从天然超分子系统设计的肽基纳米材料的最新进展，包括(1)人工病毒衣壳，(2)自组装纳米纤维和(3)蛋白质结合基序。从自然界获得灵感的多肽将为生物纳米材料的设计提供新的思路。
Natural supramolecular assemblies exhibit unique structural and functional properties that have been optimized over the course of evolution. Inspired by these natural systems, various bio-nanomaterials have been developed using peptides, proteins, and nucleic acids as components. Peptides are attractive building blocks because they enable the important domains of natural protein assemblies to be isolated and optimized while retaining the original structures and functions. Furthermore, the peptide subunits can be conjugated with exogenous molecules such as peptides, proteins, nucleic acids, and metal nanoparticles to generate advanced functions. In this personal account, we summarize recent progress in the construction of peptide-based nanomaterial designed from natural supramolecular systems, including (1) artificial viral capsids, (2) self-assembled nanofibers, and (3) protein-binding motifs. The peptides inspired by nature should provide new design principles for bio-nanomaterials.