Prevalence of subcortical vascular lesions and association with executive function in mild cognitive impairment subtypes
Prevalence of subcortical vascular lesions and association with executive function in mild cognitive impairment subtypes
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DOI：
10.1161/strokeaha.107.486407
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发表时间：
2007-09-01
期刊：
影响因子：
8.3
通讯作者：
Pasquier, Florence
中科院分区：
文献类型：
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作者：
Bombois, Stephanie;Debette, Stephanie;Pasquier, Florence
背景和目的-皮质下高信号(SH)在轻度认知损害(MCI)中尚未得到系统评估。我们试图描述它们的频率和分布，并测试它们与MCI患者认知特征的相关性。方法：我们对170名连续的MCI患者进行了标准化的神经心理测试和MRI扫描。结果：中位年龄68.1岁(45.5~87.0岁)，简易智力状态检查中位数28.0分(26.0~30.0分)。MCI亚型包括遗忘型单域(21.2%)、遗忘型多域(52.3%)、非遗忘型单域(21.8%)和非遗忘型多域(4.7%)。SH157例(92.6%)，脑室周围高信号(80.6%)和脑叶白质高信号(83.5%)。SH亚型与MCI亚型之间无相关性。执行功能障碍与SH(优势比=2.53，95%CI：1.20~5.32)、脑室周围高信号(OR=2.51，95%CI：1.13~5.55)和脑白质高信号(OR=2.08，95%CI：1.01~4.25)独立相关。高血压(尤其是脑室周围高信号和脑叶白质高信号)与执行功能障碍有关。
Background and Purpose - Subcortical hyperintensities ( SH) have not been systematically evaluated in mild cognitive impairment ( MCI). We sought to describe their frequency and distribution, and to test their association with cognitive characteristics in MCI patients. Methods - We performed standardized neuropsychological tests and an MRI scan in 170 consecutive MCI patients. Medial temporal lobe atrophy and SH, including periventricular, lobar white matter, basal ganglia and infratentorial hyperintensities, were assessed with visual semiquantitative scales.Results - The median age was 68.1 years ( range: 45.5 to 87.0), and the median Mini-Mental State Examination score 28.0 ( range: 26.0 to 30.0). MCI subtypes were amnestic single domain ( 21.2%), amnestic multiple domain ( 52.3%), nonamnestic single domain ( 21.8%), and nonamnestic multiple domain ( 4.7%). SH were found in 157 patients ( 92.6%); periventricular hyperintensities ( 80.6%) and lobar white matter hyperintensities ( 83.5%) were the most prominent locations. There was no association between SH and MCI subtypes. Executive dysfunction was independently associated with SH ( odds ratio = 2.53, 95% CI: 1.20 to 5.32), periventricular hyperintensities ( odds ratio = 2.51, 95% CI: 1.13 to 5.55), and white matter hyperintensities ( odds ratio = 2.08, 95% CI: 1.01 to 4.25).Conclusions - The prevalence of SH is high in MCI patients, irrespective of MCI subtypes. SH ( especially periventricular hyperintensities, and lobar white matter hyperintensities) are associated with executive dysfunction.