Buprenorphine in the Treatment of Opiate Dependence
Buprenorphine in the Treatment of Opiate Dependence
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丁丙诺啡治疗阿片依赖
DOI：
10.1080/02791072.2010.10400689
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发表时间：
2010
影响因子：
2.8
通讯作者：
David E. Smith
中科院分区：
文献类型：
--
作者：
D. Wesson;David E. Smith
令人信服的临床证据表明丁丙诺啡在阿片解毒和维持方面与美沙酮相似，但在过量情况下比美沙酮更安全。2000年《药物滥用治疗法案》（DATA 2000）使接受过额外培训的美国医生能够给数量有限的阿片类依赖患者开丁丙诺啡。舌下片Subutex®（单独丁丙诺啡）和Suboxone®（丁丙诺啡和纳洛酮的组合）符合DATA 2000的规格。Suboxone的目的是阻止静脉注射，与单独使用丁丙诺啡相比，它的滥用可能性更小。除孕妇外，苏博松一般被推荐用于维持治疗。Subutex被推荐用于治疗孕妇。新生儿可出现丁丙诺啡阿片类戒断综合征。虽然静脉注射丁丙诺啡滥用在一些国家是一个重大的公共卫生问题，但丁丙诺啡单独使用或与纳洛酮联合使用的滥用可能性低于海洛因和一些处方阿片类药物，如羟考酮。医生办公室的药物治疗使得一些阿片类药物依赖患者可以接受丁丙诺啡治疗，而这些患者不愿接受传统阿片类药物维持诊所的治疗。由于不充分了解的原因，一些患者发现长期使用丁丙诺啡后难以停药。本文综述了丁丙诺啡的药理作用，总结了支持丁丙诺啡安全性和有效性的证据，并提供了临床治疗指南。
Abstract Compelling clinical evidence establishes that buprenorphine is similar to methadone in efficacy for opiate detoxification and maintenance but safer than methadone in an overdose situation. The Drug Abuse Treatment Act of 2000 (DATA 2000) enabled US physicians with additional training to prescribe buprenorphine to a limited number of opiate-dependent patients. The sublingual tablets Subutex® (buprenorphine alone) and Suboxone® (a combination of buprenorphine and naloxone) meet the specifications of DATA 2000. Suboxone is intended to discourage intravenously administration and has less abuse potential than buprenorphine alone. Suboxone is generally recommended for maintenance treatment except for women who are pregnant. Subutex is recommended in treatment of pregnant women. A buprenorphine opiate withdrawal syndrome can occur in newborns. Although intravenous buprenorphine abuse is a significant public health problem in some countries, buprenorphine alone or in combination with naloxone has less potential for abuse than heroin and some prescription opiates, such as oxycodone. Pharmacotherapy from physicians' offices makes buprenorphine treatment acceptable to some opiate-dependent patients who would not accept treatment in traditional opiate-maintenance clinics. For reasons not adequately understood, some patients find discontinuation of buprenorphine following long-term use difficult. This article reviews the pharmacology of buprenorphine, summarizes evidence supporting the safety and efficacy of buprenorphine and provides clinical guidelines for treatment.
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DOI：
--
发表时间：
2001-05
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Peng Huang;George B Kehner;Alan Cowan;L. Liu-Chen
通讯作者：
Peng Huang;George B Kehner;Alan Cowan;L. Liu-Chen
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DOI：
--
发表时间：
1995
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Walsh,SL;Preston,KL;Bigelow,GE;Stitzer,ML
通讯作者：
Stitzer,ML
低剂量丁丙诺啡治疗美沙酮戒断的公开试验。
影响因子：
3.9
作者：
Banys,P;Clark,HW;Tusel,DJ;Sees,K;Stewart,P;Mongan,L;Delucchi,K;Callaway,E
通讯作者：
Callaway,E
影响因子：
--
作者：
W. Ling;D. Wesson;C. Charuvastra;Klett Cj
通讯作者：
W. Ling;D. Wesson;C. Charuvastra;Klett Cj
丁丙诺啡注射储库制剂在阿片类药物解毒中的开放标签试验。
影响因子：
4.2
作者：
Sobel,Bai-FangX;Sigmon,StaceyC;Walsh,SharonL;Johnson,RolleyE;Liebson,IraA;Nuwayser,ElieS;Kerrigan,JamesH;Bigelow,GeorgeE
通讯作者：
Bigelow,GeorgeE