Area postrema stimulation induces differential renal hemodynamics with two anesthetics.
Area postrema stimulation induces differential renal hemodynamics with two anesthetics.
复制标题
后区刺激用两种麻醉剂诱导不同的肾血流动力学。
DOI：
10.1152/ajpregu.1992.262.2.r289
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Soliman,AS
中科院分区：
文献类型：
--
作者：
Hartle,DK;Soliman,AS
比较了尿素麻醉和戊巴比妥钠麻醉sd大鼠的血压、肾血流量和肾血管阻力的变化。脲坦和戊巴比妥麻醉大鼠在APS期间平均动脉压（MAP）以频率依赖的方式升高。虽然MAP最大变化百分比组间无显著差异，但RBF和计算肾血管阻力（RVR）变化有显著差异。尿素麻醉大鼠在APS过程中RBF和MAP增加，但RVR没有变化。相比之下，APS显著降低戊巴比妥麻醉大鼠RBF(-26.5 +/- 1.9%)，增加RVR（+99.4 +/- 11.4%）。戊巴比妥麻醉组在APS期间RVR的增加被先前的神经节阻滞所消除。由此可见，所使用的麻醉剂可以显著改变黄芪多糖对大鼠肾脏血管舒缩的激活程度。
The effect of area postrema stimulation (APS) on blood pressure, renal blood flow (RBF), and renal vascular resistance was compared in urethan-anesthetized and pentobarbital sodium-anesthetized Sprague-Dawley rats. Mean arterial pressure (MAP) increased in a frequency-dependent manner during APS in both urethan- and pentobarbital-anesthetized rats. Although no significant differences occurred in the maximum percent change in MAP between groups, marked differences occurred in RBF and calculated renal vascular resistance (RVR) changes. In urethan-anesthetized rats, RBF and MAP increased during APS, but RVR did not change. In contrast, APS significantly decreased RBF (-26.5 +/- 1.9%) while increasing RVR (+99.4 +/- 11.4%) in pentobarbital-anesthetized rats. The increase in RVR in the pentobarbital-anesthetized group during APS was eliminated by prior ganglionic blockade. It was concluded that the anesthetic agent employed can significantly alter the degree to which APS can activate renal vasomotion in the rat.