Patterns of personality disorder comorbidity in early-onset versus late-onset major depression.
Patterns of personality disorder comorbidity in early-onset versus late-onset major depression.
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早发性与晚发性重度抑郁症的人格障碍合并症模式。
DOI：
10.1176/ajp.153.10.1308
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Rosenbaum,JF
中科院分区：
文献类型：
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作者：
Fava,M;Alpert,JE;Borus,JS;Nierenberg,AA;Pava,JA;Rosenbaum,JF
目的本研究验证了一项假设，即在成年抑郁症门诊患者中，早发性抑郁症患者比晚发性抑郁症患者有更大的人格障碍患病率。方法404例受试者为参加马萨诸塞州总医院抑郁症治疗研究的患者。他们接受了dsm - iii - r -患者版的结构化临床访谈，以评估当前重度抑郁症的存在和首次抑郁发作的年龄。然后将受试者分为两组：早发组（18岁之前）和晚发组（18岁或更晚）。人格障碍的患病率通过使用医师评定的DSM-III-R人格障碍结构化临床访谈（SCID-II）和患者评定的人格诊断问卷-修订版（PDQ-R）来确定。结果根据SCID-II，早发重性抑郁症患者在回避型、戏剧型、自恋型和边缘型人格障碍方面的患病率明显较高。PDQ-R评分显示，早发性抑郁症患者存在回避型、依赖型、被动攻击型、戏剧型、自恋型、边缘型和反社会型人格障碍。结论早发性抑郁症与晚发性重性抑郁症的区别在于其行为和态度的持续障碍更为频繁。
ObjectiveThis study tested the hypothesis that in a population of adult outpatients with major depression, those with an early onset of depression would have a greater prevalence of personality disorders than those with a late onset of depression.MethodThe 404 subjects were patients participating in depression treatment studies at the Massachusetts General Hospital. They were administered the Structured Clinical Interview for DSM-III-R-Patient Version to assess the current presence of major depression and the age at onset of the initial depressive episode. The subjects were then divided into two groups: those with early onset (before 18 years of age) and those with late onset (at age 18 or later). The prevalence of personality disorders was determined through use of the physician-rated Structured Clinical Interview for DSM-III-R Personality Disorders (SCID-II) and the patient-rated Personality Diagnostic Questionnaire-Revised (PDQ-R).ResultsThe patients with early onset of major depression had a significantly higher prevalence of avoidant, histrionic, narcissistic, and borderline personality disorders according to the SCID-II. The PDQ-R scores indicated that avoidant, dependent, passive-aggressive, histrionic, narcissistic, borderline, and antisocial personality disorders were significantly more prevalent among the patients with early onset of major depression.ConclusionsOverall, the results are consistent with the view that early-onset depressive illness is distinguished from late-onset major depression by more frequent association with persistent disturbances in behaviors and attitudes.