Long-chain ω-3 fatty acid supply in pregnancy and lactation
Long-chain ω-3 fatty acid supply in pregnancy and lactation
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DOI：
10.1097/mco.0b013e3282f795e6
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发表时间：
2008-05-01
影响因子：
3.1
通讯作者：
Koletzko, Berthold
中科院分区：
文献类型：
--
作者：
Cetina, Irene;Koletzko, Berthold
综述的目的长链omega-3脂肪酸是发育中的胎儿所必需的。二十二碳六烯酸是最重要的omega-3脂肪酸，是神经和视网膜膜的重要组成部分，在怀孕和出生后迅速积累在大脑中。母亲在怀孕和/或哺乳期间摄入鱼类、海鲜和omega-3脂肪酸与视觉和认知发育呈正相关。最近的发现综述了观察性和干预性研究的新发现，这些研究涉及怀孕或哺乳期omega-3脂肪酸对孕期长度和出生体重、早产、先兆子痫、母亲抑郁、婴儿视觉功能和神经发育的影响。综述：omega-3脂肪酸与降低心血管和其他疾病的风险有关。观察性和干预性研究表明，在低风险和高风险妊娠中，延长妊娠和降低早产风险具有重要的相关性。对胎儿宫内发育受限、先兆子痫和产后抑郁症有进一步的益处，但证据尚不确定。孕妇在孕期和哺乳期摄入较高的二十二碳六烯酸与积极的婴儿神经发育结局有关。育龄妇女的平均膳食二十二碳六烯酸摄入量每天至少应达到200毫克。
Purpose of reviewLong-chain omega-3 fatty acids are essential for the developing fetus. Docosahexaenoic acid, the most important omega-3 fatty acid, is an important component of neural and retinal membranes, and rapidly accumulates in the brain during gestation and the postnatal period. Positive associations have been shown between maternal intake of fish, seafood and omega-3 fatty acids during pregnancy and/or lactation and visual and cognitive development.Recent findingsThe review focuses on new findings by both observational and interventional studies on the influence of omega-3 fatty acids during pregnancy or lactation on gestation length and birth weight, preterm delivery, preeclampsia, maternal depression and infant visual function and neural development.SummaryOmega-3 fatty acids have been associated with reduced risk of cardiovascular and other diseases. Observational and interventional studies indicate a significant association with prolonging gestation and reducing the risk of preterm delivery both in low-risk and in high-risk pregnancies. Further benefits have been suggested for intrauterine growth restriction, preeclampsia and postpartum depression, but the evidence is inconclusive. Higher maternal docosahexaenoic acid intake both in pregnancy and lactation is associated with positive infant neurodevelopmental outcomes. Women of reproductive age should achieve an average dietary docosahexaenoic acid intake of at least 200 mg/day.