Early menarche is associated with insulin resistance in advanced maternal age before delivery
Early menarche is associated with insulin resistance in advanced maternal age before delivery
复制标题
初潮提前与高龄产妇分娩前的胰岛素抵抗有关
DOI：
10.1080/09513590.2019.1658731
复制
发表时间：
2019-08-30
影响因子：
2
通讯作者：
Li, Ling
中科院分区：
文献类型：
--
作者：
Dong, Beibei;Zhi, Mengmeng;Li, Ling
摘要目的：随着我国全面两孩政策的广泛实施，高龄孕产妇数量将逐渐增加。我们的目的是评估月经初潮年龄（AAM）和AMA分娩前胰岛素抵抗（IR）之间的关系。方法：80例AMA孕妇于分娩前在中大医院连续入组。根据月经规律的年龄（约13岁）将孕妇分为初潮早发组和初潮晚发组。分娩时，测量血清葡萄糖和脂质水平。采用HOMA 2法计算IR。结果如下：初潮早期组的空腹血胰岛素（分别为17.68（9.72-36.71）和10.35（7.76-15.10）; p = .006）和HOMA-IR（分别为2.08（1.18-4.37）和1.24（0.89-1.78）; p = .005）高于初潮晚期组。AAM与AMA的HOMA-IR呈负相关（r=-0.27，p = 0.014）。在多变量分析中，与初潮早期组相比，初潮晚期组的AAM与HOMA-IR水平呈负相关（β= −2.275，p≤.0001）。结论：总而言之，我们的研究结果表明AAM与AMA中的HOMA-IR呈负相关。月经初潮早的孕妇HOMA-IR水平可能高于月经初潮晚的孕妇。临床试验注册：中国临床试验注册中心（编号：ChiCTR-RRC-16008714），回顾性注册
Abstract Purpose: With the wide implementation of the universal two-child policy in China, the number of pregnant women in advanced maternal age (AMA) will increase gradually. We aimed to assess the association between age at menarche (AAM) and insulin resistance (IR) before delivery in AMA. Methods: A total of 80 pregnant women in AMA were consecutively enrolled before delivery in Zhongda hospital. Pregnant women were stratified into early menarche group and late menarche group according to the age of regular menstruation (about 13 years). At delivery, serum glucose and lipid levels were measured. IR was calculated by the method of homeostasis model assessment 2(HOMA2). Results: The fasting blood insulin (17.68(9.72–36.71) and 10.35(7.76–15.10), respectively; p = .006) and HOMA-IR (2.08(1.18–4.37) and 1.24(0.89–1.78), respectively; p = .005) were higher in early menarche group than in late menarche group. AAM was inversely associated with HOMA-IR in AMA (r= −0.27, p = .014). In the multivariable analysis, AAM in late menarche group was negatively related to the level of HOMA-IR compared to those in early menarche group (β= −2.275, p≤.0001). Conclusions: Taken together, our findings suggest that AAM was inversely associated with HOMA-IR in AMA. Furthermore, pregnant women in AMA with early menarche might have higher HOMA-IR levels than those with late menarche. Clinical trial registration: Chinese Clinical Trial Registry (No. ChiCTR-RRC-16008714), retrospectively registered