Neural correlates for angular head velocity in the rat dorsal tegmental nucleus
Neural correlates for angular head velocity in the rat dorsal tegmental nucleus
复制标题
DOI：
10.1523/jneurosci.21-15-05740.2001
复制
发表时间：
2001-08-01
影响因子：
5.3
通讯作者：
Taube, JS
中科院分区：
文献类型：
--
作者：
Bassett, JP;Taube, JS
大鼠乳头体外侧核（LMN）中的许多神经元在水平面上与动物的头部方向（HD）相关地选择性放电，而与大鼠的位置或行为无关。这种表征是如何产生和更新的一个假设是通过背盖核（DTN）的皮层下投射。在这里，我们报告的DTN神经元的活动类型。大多数细胞（75%）作为大鼠头部角速度（AHV）的函数发射。细胞表现出两种类型的放电模式之一：（1）对称性，其中在两个方向上头部转动期间，放电频率与AHV正相关，以及（2）不对称性，其中放电频率与头部转动在一个方向上正相关，并且在相反方向上负相关或根本不相关。除了AHV的调节外，一些AHV细胞（40.1%）还受到大鼠线速度的微弱调节，少数AHV细胞受到HD（11%）或头部俯仰（15.9%）的调节。自相关分析表明，与头部静止，AHV细胞显示不规则的放电模式。由于来自DTN的传入是投射到LMN的信息的主要来源，因此这些结果表明来自DTN的AHV信息在LMN中产生HD信号方面发挥着重要作用。提出了一个模型，显示DTN AHV细胞如何生成和更新LMN HD细胞信号。
Many neurons in the rat lateral mammillary nuclei (LMN) fire selectively in relation to the animal's head direction (HD) in the horizontal plane independent of the rat's location or behavior. One hypothesis of how this representation is generated and updated is via subcortical projections from the dorsal tegmental nucleus (DTN). Here we report the type of activity in DTN neurons. The majority of cells (75%) fired as a function of the rat's angular head velocity (AHV). Cells exhibited one of two types of firing patterns: (1) symmetric, in which the firing rate was positively correlated with AHV during head turns in both directions, and (2) asymmetric, in which the firing rate was positively correlated with head turns in one direction and correlated either negatively or not at all in the opposite direction. In addition to modulation by AHV, some of the AHV cells (40.1%) were weakly modulated by the rat's linear velocity, and a smaller number were modulated by HD (11%) or head pitch (15.9%). Autocorrelation analyses indicated that with the head stationary, AHV cells displayed irregular discharge patterns. Because afferents from the DTN are the major source of information projecting to the LMN, these results suggest that AHV information from the DTN plays a significant role in generating the HD signal in LMN. A model is proposed showing how DTN AHV cells can generate and update the LMN HD cell signal.