Global longitudinal strain aids the detection of non-obstructive coronary artery disease in the resting echocardiogram
Global longitudinal strain aids the detection of non-obstructive coronary artery disease in the resting echocardiogram
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DOI：
10.1093/ejechocard/jer282
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发表时间：
2012-07-01
影响因子：
6.2
通讯作者：
Ogunyankin, Kofo O.
中科院分区：
文献类型：
--
作者：
Montgomery, David E.;Puthumana, Jyothy J.;Ogunyankin, Kofo O.
目的探讨静息超声心动图异常总纵应变（GLS）对非阻塞性冠状动脉疾病（CAD）的诊断价值。利用二维斑点跟踪超声心动图（2D STE）进行GLS是检测晚期CAD的有力工具。然而，2D STE从静止图像中检测中度、临床不明显的CAD的诊断能力尚不清楚。方法和结果我们回顾性研究了123例连续患者的二维STE特征，这些患者在10天内接受了应激超声心动图检查，并随后进行了冠状动脉造影。我们比较了静息时GLS与常规应激时壁运动评分指数（WMSI）在检测任何主要冠状动脉狭窄(> = 50% （CAD(>50)）方面的诊断能力。排除运动或运动障碍节段和左心室射血分数降低的研究。在56例明显CAD（bbb50）患者中，应激时测量的GLS为-16.77 +/- 3.18%，而67例无CAD患者的GLS为-19.05 +/- 3.43%（= 1.13(68/70%)）。结论在静止图像中，2D STE测量的GLS降低可识别非阻塞性CAD，其准确性与传统应激超声心动图测量的WMSI相似。
Aims To evaluate the diagnostic power of abnormal global longitudinal strain (GLS) to detect non-obstructive coronary artery disease (CAD) in the resting echocardiogram. GLS using two-dimensional speckle-tracking echocardiography (2D STE) is a powerful tool for detecting advanced CAD. However, the diagnostic power of 2D STE for detecting moderate, clinically unapparent CAD from images obtained at rest is unknown.Methods and results We retrospectively studied 2D STE characteristics in 123 consecutive patients who underwent stress echocardiography, and subsequently coronary angiography within 10 days. We compared the diagnostic power of GLS at rest to the conventional wall motion score index (WMSI) during stress for detecting stenosis >= 50% (CAD(>50)) in any major coronary artery. Studies with akinetic or dyskinetic segments and reduced left ventricular ejection fraction were excluded. In 56 patients with significant CAD(>50), GLS was -16.77 +/- 3.18% compared with -19.05 +/- 3.43% in the 67 patients without CAD(= 1.13 (68/70%) measured during stress.Conclusion Non-obstructive CAD was identified by a reduced GLS measured by 2D STE in rest images with similar accuracy to the traditional WMSI measured in stress echocardiography.