Selective separation of zwitterionic phospholipid homologues with functional ionic liquids as extractants
Selective separation of zwitterionic phospholipid homologues with functional ionic liquids as extractants
复制标题
以功能离子液体为萃取剂选择性分离两性离子磷脂同系物
DOI：
10.1039/c5ra14202d
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发表时间：
2015
期刊：
影响因子：
3.9
通讯作者：
Huabin Xing
中科院分区：
文献类型：
--
作者：
Jingzhu Zhang;Kun Yu;Qiwei Yang;Zongbi Bao;Zhiguo Zhang;Yiwen Yang;Qilong Ren;Huabin Xing
天然两性离子化合物被广泛用作表面活性剂、药物和食品添加剂。然而，由于植物中存在结构相似的同系物，从生物质中获得高纯度的两性离子仍然具有挑战性。在这里，我们开发了一种以离子液体(ILS)为萃取剂分离两性离子磷脂同系物的新方法。以羟基官能化和羧基官能化离子液体为萃取剂，磷脂酰胆碱具有较大的分配系数和良好的分离选择性。为了减少IL的消耗，提高提取效率，本研究采用了一种有效的IL-助溶剂提取策略。此外，通过从头计算和动态光散射对萃取机理进行了探讨。结果表明，IL与两性离子的正负部分均存在多重氢键作用，并在IL-助溶剂混合物中形成了胶束。此外，考察了离子液体的结构、浓度和温度对萃取性能的影响，并对电渗析回收离子液体的可行性进行了评价。
Natural zwitterionic compounds are widely used as surfactants, drugs and food additives. However, obtaining high-purity zwitterions from biomass remains challenging because of the presence of structurally similar homologues in plants. Here, we developed a novel extraction method to separate zwitterionic phospholipid homologues using ionic liquids (ILs) as extractants. A large distribution coefficient and excellent separation selectivity for phosphatidylcholine (PC) were achieved with hydroxyl-functionalized and carboxyl-functionalized ILs as the extractants. An effective IL–cosolvent extraction strategy was employed in this work to reduce the consumption of IL and improve the extraction efficiency. Additionally, the underlying extraction mechanism was explored using ab initio calculations and dynamic light scattering. The results indicated the existence of multiple hydrogen-bonding interactions between the IL and both the negative and positive moieties of the zwitterion, and the formation of micelles in the IL–cosolvent mixture was also observed. In addition, the effects of the structure and concentration of ILs and the temperature on extraction performance were investigated, and the feasibility of recovery of ILs by electrodialysis was evaluated.