CENTRAL CONTROL OF SHIVERING AND NON-SHIVERING THERMOGENESIS IN RAT
CENTRAL CONTROL OF SHIVERING AND NON-SHIVERING THERMOGENESIS IN RAT
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DOI：
10.1113/jphysiol.1978.sp012520
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发表时间：
1978-01-01
影响因子：
5.5
通讯作者：
LIEBERMANN, H
中科院分区：
文献类型：
--
作者：
BANET, M;HENSEL, H;LIEBERMANN, H
为了测试视前区是否仅控制非颤抖和脊髓仅生热，10只大鼠分别长期植入视前区和脊髓热电极。研究了普萘洛尔（8 mg/kg/h）对冷却视前区和脊髓的代谢反应的影响，外源性去甲肾上腺素[去甲肾上腺素]（0.5 mg/kg）对冷却视前区和脊髓的代谢反应的影响，以及加热视前区对冷却脊髓的代谢反应的影响，反之亦然。普萘洛尔的管理抑制代谢反应，冷却每个热敏区，但冷却视前区的反应比冷却脊髓更强烈的抑制。外源性去甲肾上腺素的管理并没有阻止代谢反应冷却视前区或脊髓。加热脊髓完全抑制了对冷却视前区的代谢反应，并且加热视前区完全抑制了对冷却脊髓的代谢反应。显然，外源性去甲肾上腺素低估了非颤抖性产热的能力，两个热敏区可以控制两种形式的产热。视前区非寒战性产热阈值可能低于寒战性产热阈值，脊髓寒战性产热阈值可能低于非寒战性产热阈值。
To test whether the preoptic area controls only non-shivering and the spinal cord only thermogenesis, 10 rats were chronically implanted with a preoptic and a spinal cord thermode each. The effect of propranolol (8 mg/kg per h) on the metabolic response to cooling the preoptic area and the spinal cord, the effect of exogenous noradrenaline [norepinephrine] (0.5 mg/kg) on the metabolic response to cooling the preoptic area and the spinal cord and the effect of warming the preoptic area on the metabolic response to cooling the spinal cord and vice versa were studied. Administration of propranolol inhibited the metabolic response to cooling each of the thermosensitive areas, but the response to cooling the preoptic area was more strongly inhibited than that to cooling the spinal cord. Administration of exogenous noradrenaline did not prevent the metabolic response to cooling either the preoptic area or the spinal cord. Warming the spinal cord completely inhibited the metabolic response to cooling the preoptic area, and warming the preoptic area fully inhibited the metabolic response to cooling the spinal cord. Apparently exogenous noradrenaline underestimates the capacity for non-shivering thermogenesis and both thermosensitive areas can control both forms of thermogenesis. The preoptic areas threshold of non-shivering thermogenesis is probably lower than that of shivering, while the spinal cord threshold of shivering is probably lower than that of non-shivering thermogenesis.