Control of central and peripheral tolerance by Aire.
Control of central and peripheral tolerance by Aire.
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DOI：
10.1111/j.1600-065x.2011.01008.x
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发表时间：
2011-05
影响因子：
8.7
通讯作者：
Anderson MS
中科院分区：
文献类型：
--
作者：
Metzger TC;Anderson MS
自身反应性胸腺细胞的阴性选择取决于髓质胸腺上皮细胞对组织特异性抗原的诱导。自身免疫调节蛋白 (Aire) 在开启这些抗原方面发挥着重要作用，即使胸腺中缺乏一种 Aire 诱导的组织特异性抗原，也会导致表达抗原的靶器官发生自身免疫。最近，在外周淋巴器官中检测到了Aire蛋白，表明外周Aire蛋白在此发挥着补充作用。在这些外周位点，Aire 被发现调节一组组织特异性抗原的表达，这些抗原与胸腺中表达的抗原不同。此外，胸腺外 Aire 表达细胞 (eTAC) 中的转基因抗原表达可以介导缺失耐受，但 Aire 依赖性内源性组织特异性抗原的免疫学相关性仍有待确定。
The negative selection of self-reactive thymocytes depends on the induction of tissue-specific antigens by medullary thymic epithelial cells. The autoimmune regulator (Aire) protein plays an important role in turning on these antigens, and the absence of even one Aire-induced tissue-specific antigen in the thymus can lead to autoimmunity in the antigen-expressing target organ. Recently, Aire protein has been detected in peripheral lymphoid organs, suggesting that peripheral Aire plays a complementary role here. In these peripheral sites, Aire was found to regulate the expression of a group of tissue-specific antigens that is distinct from those expressed in the thymus. Furthermore, transgenic antigen expression in extrathymic Aire-expressing cells (eTACs) can mediate deletional tolerance, but the immunological relevance of Aire-dependent, endogenous tissue-specific antigens remains to be determined.