Working memory performance among childhood brain tumor survivors.
Working memory performance among childhood brain tumor survivors.
复制标题
DOI：
10.1017/s1355617712000793
复制
发表时间：
2012-11
影响因子：
2.6
通讯作者：
Xiong, Xiaoping
中科院分区：
文献类型：
--
作者：
Conklin, Heather M.;Ashford, Jason M.;Howarth, Robyn A.;Merchant, Thomas E.;Ogg, Robert J.;Santana, Victor M.;Reddick, Wilburn E.;Wu, Shengjie;Xiong, Xiaoping
虽然对接受脑肿瘤治疗的儿童的纵向研究一直显示智力功能下降，但治疗后更详细的认知变化对于隔离脆弱的神经系统和制定有针对性的干预措施至关重要。因此，这项横断面研究评估了接受适形放疗的儿童脑肿瘤幸存者（n= 50）、未接受CNS定向治疗的实体瘤幸存者（n= 40）和健康同胞对照（n= 40）在工作记忆[数字广度和计算机自序搜索（SOS）任务]测量方面的表现。研究结果显示，儿童脑肿瘤幸存者在传统的[数字跨度向后- F（2，127）= 5.98，p< .01]和实验[SOS-言语- F（2，124）= 4.18，p< .05; SOS-对象- F（2，126）= 5.29，p< .01]工作记忆的测量，工作记忆测试的表现与智力功能相关（数字广度向后- r= 0.45，p<0.0001; SOS- r=-0.32-0.26，p<0.01）。比较工作记忆任务的识别记忆任务（电脑延迟匹配到样本）的性能提供了一些支持更大的工作记忆障碍。这一发现模式与包括前额叶脑区在内的功能网络的脆弱性相一致，并对脑肿瘤儿童的临床管理产生影响。
While longitudinal studies of children treated for brain tumors have consistently revealed declines on measures of intellectual functioning, greater specification of cognitive changes following treatment is imperative for isolating vulnerable neural systems and developing targeted interventions. Accordingly, this cross-sectional study evaluated the performance of childhood brain tumor survivors (n= 50) treated with conformal radiation therapy, solid tumor survivors (n= 40) who had not received CNS-directed therapy, and healthy sibling controls (n= 40) on measures of working memory [Digit Span and computerized self-ordered search (SOS) tasks]. Findings revealed childhood brain tumor survivors were impaired on both traditional [Digit Span Backward- F(2, 127)= 5.98, p< .01] and experimental [SOS-Verbal- F(2, 124)= 4.18, p< .05; SOS-Object- F(2, 126)= 5.29, p< .01] measures of working memory, and performance on working memory measures correlated with intellectual functioning (Digit Span Backward- r= .45, p< .0001; SOS- r= −.32 − −.26, p< .01). Comparison of performance on working memory tasks to recognition memory tasks (computerized delayed match-to-sample) offered some support for greater working memory impairment. This pattern of findings is consistent with vulnerability in functional networks that include prefrontal brain regions and has implications for the clinical management of children with brain tumors.