Cell cycle control factors and skeletal development
Cell cycle control factors and skeletal development
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DOI：
10.1016/j.jdsr.2013.03.001
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发表时间：
2013-05
影响因子：
6.6
通讯作者：
T. Ogasawara
中科院分区：
文献类型：
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作者：
T. Ogasawara
在口腔颌面部，拔牙后骨愈合延迟、骨折、创伤引起的骨或软骨缺损以及肿瘤或出生缺陷等情况很常见，有必要确定控制骨骼发生或细胞分化的分子机制，以便为这些情况建立新的治疗策略。已经进行了多项研究来调查可能对骨骼发生或细胞分化至关重要的因子的参与，包括转录因子、生长因子和细胞周期因子。在研究中已经产生了几种细胞周期因子的基因工程小鼠模型，以确定参与细胞分化、致癌等的细胞周期因子。许多研究小组也报道了细胞周期因子在成骨细胞、破骨细胞、软骨细胞和其他细胞类型分化中的重要性。在此，我们回顾了细胞周期因子基因工程小鼠模型的表型，特别关注小鼠的大小，体重和骨骼异常，并讨论了细胞周期因子作为临床应用靶点的潜力。
In the oral and maxillofacial region, conditions such as delayed bone healing after tooth extraction, bone fracture, trauma-induced bone or cartilage defects, and tumors or birth defects are common, and it is necessary to identify the molecular mechanisms that control skeletogenesis or the differentiation of cells, in order to establish new treatment strategies for these conditions. Multiple studies have been conducted to investigate the involvement of factors that may be crucial for skeletogenesis or the differentiation of cells, including transcription factors, growth factors and cell cycle factors. Several genetically engineered mouse models of cell cycle factors have been generated in research seeking to identify cell cycle factor(s) involved in the differentiation of cells, carcinogenesis, etc. Many groups have also reported the importance of cell cycle factors in the differentiation of osteoblasts, osteoclasts, chondrocytes and other cell types. Herein, we review the phenotypes of the genetically engineered mouse models of cell cycle factors with a particular focus on the size, body weight and skeletal abnormalities of the mice, and we discuss the potential of cell cycle factors as targets of clinical applications.