Using Functional Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications
Using Functional Nanomaterials to Target and Regulate the Tumor Microenvironment: Diagnostic and Therapeutic Applications
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使用功能纳米材料靶向和调节肿瘤微环境：诊断和治疗应用
DOI：
10.1002/adma.201300299
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发表时间：
2013-07-12
影响因子：
29.4
通讯作者：
Nie, Guangjun
中科院分区：
文献类型：
--
作者：
Ji, Tianjiao;Zhao, Ying;Nie, Guangjun
恶性肿瘤仍然是全世界的主要健康负担，迫切需要有效的治疗策略。癌症纳米技术作为一个综合平台，有可能极大地改善癌症诊断、成像和治疗，同时降低与当前方法相关的毒性。肿瘤微环境是各种间质细胞和细胞外基质的集合表现。最近在了解肿瘤微环境对肿瘤进展的关键作用和潜在机制方面的进展，导致了专门针对微环境成分设计和设计的新型诊断和治疗纳米材料。同时，肿瘤和正常组织之间的生物物理化学差异最近被用来实现肿瘤的特异性靶向，用于癌症的诊断和治疗。本文综述了肿瘤微环境中的主要因素及其生化特性，可用于设计具有潜在靶向和调节这一生态位的多功能纳米材料。重点介绍了用于靶向和调节肿瘤微环境的工程化、智能化和多功能纳米材料的最新进展。尽管需要进一步的研究来开发更具体的肿瘤靶向和良好控制的纳米材料的强大方法，但基于肿瘤微环境调控的纳米技术用于更安全和更有效的抗癌纳米药物的应用已被证明是成功的，并最终将彻底改变目前的癌症治疗格局。
Malignant tumors remain a major health burden throughout the world and effective therapeutic strategies are urgently needed. Cancer nanotechnology, as an integrated platform, has the potential to dramatically improve cancer diagnosis, imaging, and therapy, while reducing the toxicity associated with the current approaches. Tumor microenvironment is an ensemble performance of various stromal cells and extracellular matrix. The recent progress in understanding the critical roles and the underlying mechanisms of the tumor microenvironment on tumor progression has resulted in emerging diagnostic and therapeutic nanomaterials designed and engineered specifically targeting the microenvironment components. Meanwhile, the bio‐physicochemical differences between tumor and normal tissues have recently been exploited to achieve specific tumor‐targeting for cancer diagnosis and treatment. Here, the major players in the tumor microenvironment and their biochemical properties, which can be utilized for the design of multifunctional nanomaterials with the potential to target and regulate this niche, are summarized. The recent progress in engineering intelligent and versatile nanomaterials for targeting and regulating the tumor microenvironment is emphasized. Although further investigations are required to develop robust methods for more specific tumor‐targeting and well‐controlled nanomaterials, the applications of tumor microenvironment regulation‐based nanotechnology for safer and more effective anticancer nanomedicines have been proven successful and will eventually revolutionize the current landscape of cancer therapy.