Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials.
Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials.
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血管紧张性心绞痛中的血栓素 A2：来自直接测量和抑制剂试验的证据。
DOI：
10.1056/nejm198104233041703
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Oates,JA
中科院分区：
文献类型：
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作者：
Robertson,RM;Robertson,D;Roberts,LJ;Maas,RL;FitzGerald,GA;Friesinger,GC;Oates,JA
血栓素 A2(TxA2) 是一种花生四烯酸代谢物，可引起血管收缩和血小板聚集，是冠状动脉血管痉挛的假定介质。为了确定血小板释放的 TxA2 是否会引起冠状动脉血管痉挛，我们测量了 7 名患者的桡动脉和冠状窦血中的血浆血栓素 B2（TxB2，TxA2 的非活性水合产物），并对 9 名患者进行了抗血小板药物的治疗试验。尽管自发性缺血时冠状窦 TxB2 水平从基线上升约五倍，但缺血早期采集的样本显示没有超过基线值上升。尽管 150 毫克剂量的阿司匹林可将尿二诺-TxB2 水平降低 75% 以上，但它对血管痉挛引起的慢性复发性心绞痛（“血管紧张性心绞痛”）的病程没有影响。同样，吲哚美辛对缺血的频率或持续时间没有影响。 TxA2 不太可能引起血管紧张性心绞痛，但它可能在冠状血管痉挛期间释放。 （新英格兰医学杂志，1981 年；304：998–1003。）
Thromboxane A2(TxA2), an arachidonic acid metabolite causing vasoconstriction and platelet aggregation, is a putative mediator of coronary-artery vasospasm. To determine whether platelet-released TxA2causes coronary arterial vasospasm, we measured plasma thromboxane B2(TxB2, the inactive hydration product of TxA2) in the radial-artery and coronary-sinus blood of seven patients and performed therapeutic trials of antiplatelet agents in nine. Although coronary-sinus TxB2levels rose from the base line approximately fivefold with spontaneous ischemia, samples drawn early in ischemia showed no rise over base-line values. Although a 150-mg dose of aspirin reduced urinary dinor-TxB2levels by over 75 per cent, it had no effect on the course of the chronic recurrent form of angina pectoris due to vasospasm ("vasotonic angina"). Similarly, indomethacin had no effect on the frequency or duration of ischemia. TxA2is unlikely to cause vasotonic angina, but it may be released during coronary vasospasm. (N Engl J Med. 1981; 304:998–1003.)