VIRULENCE PROPERTIES OF ESCHERICHIA-COLI STRAINS IN PATIENTS WITH CHRONIC PYELONEPHRITIS
VIRULENCE PROPERTIES OF ESCHERICHIA-COLI STRAINS IN PATIENTS WITH CHRONIC PYELONEPHRITIS
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DOI：
10.1007/bf01643482
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发表时间：
1986-01-01
期刊：
影响因子：
7.5
通讯作者：
WESSEL, G
中科院分区：
文献类型：
--
作者：
FUNFSTUCK, R;TSCHAPE, H;WESSEL, G
对50株慢性肾盂肾炎患者膀胱穿刺液中分离到的大肠埃希菌进行了毒力特性测定。从26例肾盂肾炎急性发作中分离到的大肠埃希菌均呈光滑形态。30%的人有K1抗原，77%的人有形成溶血素的能力，30%的人产生结肠素V(需氧菌)。81%的细菌登记了菌毛(通过抗甘露糖血凝检测)，70%的细菌含有介于50-70md之间的质粒。相反，从2 4例肾盂肾炎稳定期患者分离的大肠杆菌中，只有70%的菌株呈光滑形态，其中10%的编码K1抗原、2 0%的溶血素和10%的Colicin V质粒在5 0~70md范围内。在多元方差分析和判别分析的基础上，证实了泌尿系致病菌株具有多种毒力特性，其中甘露糖抗性血凝作用尤为重要。
In 50 Escherichia coli strains obtained from the bladder puncture urine of patients with chronic pyelonephritis, determinations of virulence properties were performed. All of the E. coli strains isolated from 26 acute episodes of pyelonephritis were found in the smooth form. 30% possessed K 1 antigen, 77% showed the ability to form hemolysin and 30% produced colicin V (aerobactin). Fimbriae (detected by mannose-resistant hemagglutination) were registered in 81%, and plasmids ranging between 50 and 70 Md were demonstrated in 70% of the bacteria. In contrast to this, only 70% of the E. coli strains isolated from 24 patients at an inactive stage of pyelonephritis were found in the smooth form; 10% of these encoded K 1 antigen, 20% hemolysin and 10% colicin V. Plasmids in the range 50 to 70 Md could be found in 30%. On the basis of multivariate analysis of variance and discriminant analysis, it was confirmed that uropathogenic strains possess several virulence properties, mannose-resistant hemagglutination being of particular importance.