The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy
The bioinorganic and medicinal chemistry of carboranes: from new drug discovery to molecular imaging and therapy
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DOI：
10.1039/b709843j
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发表时间：
2007-01-01
影响因子：
4
通讯作者：
Valliant, John F.
中科院分区：
文献类型：
--
作者：
Armstrong, Andrea F.;Valliant, John F.
近年来，碳硼烷在药物化学中的作用多样化，现已扩展到药物发现、分子成像和靶向放射性核素治疗等领域。介绍碳硼烷化学是为了让非专家熟悉这些分子的一些关键性质，随后是对目前涉及碳硼烷的医学研究的概述。说明了这项研究的广泛性质，强调了这一领域的最新亮点和进展。
The role of carboranes in medicinal chemistry has diversified in recent years and now extends into areas of drug discovery, molecular imaging, and targeted radionuclide therapy. An introduction to carborane chemistry is provided to familiarize the non-expert with some key properties of these molecules, followed by an overview of current medicinally-orientated research involving carboranes. The broad-ranging nature of this research is illustrated, with emphasis placed on recent highlights and advances in this field.