Differentiation between two forms of angiotonin by means of spirally cut strips of rabbit aorta.
Differentiation between two forms of angiotonin by means of spirally cut strips of rabbit aorta.
复制标题
通过兔主动脉的螺旋切割条区分两种形式的血管紧张素。
DOI：
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发表时间：
1957
影响因子：
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通讯作者：
O. M. Helmer
中科院分区：
文献类型：
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作者：
O. M. Helmer
通过对兔胸主动脉的螺旋切割，血管紧张素以两种形式存在。其中一种是血管紧张素II，它能引起血管条收缩。另一种是血管紧张素I，它是无活性的。在动物体内静脉注射时，它们同样具有升压作用。血浆中的酶将无活性形式转化为活性形式。相同的升压活性可以解释为在完整动物的血浆中过量的转换酶，它可以迅速将血管紧张素I转化为血管紧张素II。一些高血压患者血浆中转化酶的含量高于血压正常者。除转化酶外，血浆中的其他因子可增强血管紧张素和儿茶酚胺诱导主动脉条收缩的能力。这些因素可能使肌肉中建立收缩过程的机制变得敏感。
By means of a spirally cut strip of rabbit thoracic aorta, it has been shown that angiotonin exists in two forms. One form, angiotonin II, causes a contraction of the strip. The other, angiotonin I, is inactive. They are equally pressor when injected intravenously in animals. An enzyme in plasma converts the inactive form to the active form. The identical pressor activity can be explained by the excess of the converting enzyme in the plasma of the intact animal which rapidly converts angiotonin I to angiotonin II. Some patients with hypertension have a greater content of the converting enzyme in their plasma than is found in plasma of normotensive subjects. In addition to the converting enzyme, other factors in plasma enhance the ability of angiotonin and catechol amines to induce constriction of the strip of aorta. These factors may sensitize the mechanisms in the muscle which set up the process of contraction.