Age-related reductions in the excitability of phasic dorsal root ganglion neurons innervating the urinary bladder in female rats
Age-related reductions in the excitability of phasic dorsal root ganglion neurons innervating the urinary bladder in female rats
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雌性大鼠支配膀胱的阶段性背根神经节神经元兴奋性与年龄相关的降低
DOI：
10.1016/j.brainres.2020.147251
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发表时间：
2021-01
期刊：
影响因子：
2.9
通讯作者：
Zhang Xiulin
中科院分区：
文献类型：
--
作者：
Wen Jiliang;Chen Zhenghao;Wang Si;Zhao Mengmeng;Wang Shaoyong;Zhao Shengtian;Zhang Xiulin
Previous studies have revealed an impairment in bladder sensory transduction in aged animals. To examine the contributions of electrical property changes of bladder primary afferents to this impairment, we compared the electrical properties of dorsal root ganglion (DRG) neurons innervating the bladder among young (3 months), middle-aged (12 months), and old (24 months) female rats. The DRG neurons were labeled using axonal tracing techniques. Whole-cell current-clamp recordings of small and medium-sized neurons were performed to assess their passive and active properties. Two patterns of firing were identified based on responses to super-threshold stimuli (1.5, 2.0, 2.5, and 3.0 × rheobase): tonic neurons fired more action potentials (APs), whereas phasic neurons fired only one AP at the onset of stimulus. Tonic neurons were smaller and had a slower rate of AP rise, longer AP duration, more depolarized voltage threshold, and greater rheobase than phasic neurons. In phasic neurons, there was an age-associated increase in voltage threshold and an increase of rheobase (P< 0.05), suggesting an age-related decrease in excitability. In addition, both middle-aged and old rats had longer AP durations and slower rates of AP rise than young rats (P< 0.05). In tonic neurons, old rats had a greater AP overshoot and greater rate of AP rise, but no age-associated changes were identified in any other electrical properties. Our results suggest that the electrical properties of tonic and phasic bladder afferents are differentially altered with aging. A decrease in excitability may contribute to age-related reductions in bladder sensory function.
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DOI：
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发表时间：
2008
期刊：
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影响因子：
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通讯作者：
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期刊：
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影响因子：
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