Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.
Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.
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Aspergilones A 和 B，两种苄基氮杂酮，具有前所未有的碳骨架，来自柳珊瑚衍生真菌 Aspergillus sp。
DOI：
10.1016/j.bmcl.2010.12.005
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发表时间：
2011-01-15
影响因子：
2.7
通讯作者：
Lin, Yong-Cheng
中科院分区：
文献类型：
--
作者：
Shao, Chang-Lun;Wang, Chang-Yun;Lin, Yong-Cheng
从一种海洋真菌Aspergillus sp.的培养液中分离到两种新的具有前所未有的碳骨架的苄基氮杂菲酮衍生物曲霉酮A（1）和其具有独特亚甲基桥的对称二聚体曲霉酮B（2）。它们的结构和1和2的相对立体化学使用NMR光谱和X-射线晶体学的组合来阐明。化合物1不仅表现出体外选择性细胞毒性，而且还表现出强的抗肿瘤活性。(C)2010爱思唯尔有限公司版权所有。
Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. (C) 2010 Elsevier Ltd. All rights reserved.