Disruption of scale development by Delta-1 misexpression
Disruption of scale development by Delta-1 misexpression
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DOI：
10.1006/dbio.1997.8844
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发表时间：
1998-03-01
影响因子：
2.7
通讯作者：
Niswander, L
中科院分区：
文献类型：
--
作者：
Crowe, R;Niswander, L
Notch及其配体是参与许多细胞命运决定的分子，由于该信号系统在胚胎鸡羽毛和光滑皮肤命运的选择中所起的作用，我们试图测试Notch信号是否也可能在决定鳞片命运中起作用，Notch-1和-2锯齿-1和-2以及Delta-1在鳞片发育过程中表达。使用具有复制能力的逆转录病毒错误表达鸡δ -1会导致区域规模损失。此外，在一些鳞片上经常观察到羽芽。这些结果表明，在一个模型中，Delta可以作为皮肤附属物命运的抑制剂以及羽毛命运的促进剂。(C) 1998学术出版社。
Notch and its ligands are molecules known to be involved in many cell fate decisions, Due to the proposed role of this signaling system in the choice between feather and smooth skin fate in the embryonic chick, we sought to test whether Notch signaling may also play a role in determining scale fate, Notch-1 and -2 Serrate-1 and -2, and Delta-1 are expressed in the scales throughout their development. Misexpression of chick Delta-1 using a replication-competent retrovirus results in regions of scale loss. In addition, feather buds are often observed on some of the scuta scales. These results suggest a model in which Delta can act as an inhibitor of skin appendage fate as well as a promoter of feather fate. (C) 1998 Academic Press.