Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis
Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis
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DOI：
10.1007/s10549-009-0467-1
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发表时间：
2010-02-01
影响因子：
3.8
通讯作者：
Sergentanis, Theodoros N.
中科院分区：
文献类型：
--
作者：
Economopoulos, Konstantinos P.;Sergentanis, Theodoros N.
MDM2 SNP309是位于MDM2基因内含子1的单核苷酸T&gT；G多态。已经发表了各种病例对照研究，评估MDM2 SNP309与乳腺癌风险之间的关联。然而，已发表的研究以及随后的荟萃分析都产生了相互矛盾的结果。这项荟萃分析旨在研究MDM SNP309基因多态性是否会随着种族的不同而对乳腺癌风险产生不同的影响。通过搜索MEDLINE、Cochrane和EMBASE书目数据库1993年7月至2009年6月期间的符合条件的文章；16项病例对照研究符合条件(12,986例乳腺癌病例，12,993例对照)。对中国人(3项研究，892例，对照1,435例)和非中国人(13项研究，12,094例，11,558例对照)进行了病例对照研究。所有的合并优势比(OR)都来自固定效应模型，因为研究间的异质性在统计学上并不显著。对中国受试者的进一步分析显示，GT和GG基因与乳腺癌风险增加相关(合并OR=1.272，95%CI 1.025~1.578和合并OR=1.323，95%CI 1.034~1.694)，因此G等位基因的总体效应具有统计学意义(合并OR=1.287，95%CI 1.048~1.579)。相反，在非中国人群中，MDM2 SNP309状态与乳腺癌风险之间没有明显的关联。综上所述，MDM2 SNP309与乳腺癌的关联被RACE改变。MDM2 SNP309是中国女性乳腺癌的危险因素，但在非中国女性中不是。这种现象类似于在肺癌的背景下描述的。
MDM2 SNP309 is a single nucleotide T > G polymorphism present in intron 1 of the MDM2 gene. A variety of case-control studies have been published evaluating the association between MDM2 SNP309 and breast cancer risk. However, the published studies, as well as the subsequent meta-analyses, have yielded contradictory results. This meta-analysis aims to examine whether MDM SNP309 polymorphism may exert a differential effect on breast cancer risk along with race. Eligible articles were identified by a search of MEDLINE, Cochrane and EMBASE bibliographical databases for the period July 1993 to June 2009; 16 case-control studies were eligible (12,986 breast cancer cases, 12,993 controls). Subanalyses in case-control studies conducted on Chinese (3 studies, 892 cases, 1,435 controls) and non-Chinese populations (13 studies, 12,094 cases, 11,558 controls) were performed. All pooled odds ratios (ORs) were derived from fixed-effects models given that the between-study heterogeneity was not statistically significant. Subanalysis on Chinese subjects demonstrated that GT and GG genotype were associated with increased breast cancer risk (pooled OR = 1.272, 95% CI 1.025-1.578 and pooled OR = 1.323, 95% CI 1.034-1.694, respectively); as a result the overall effect of the G allele was statistically significant (pooled OR = 1.287, 95% CI 1.048-1.579). On the contrary, no significant associations between MDM2 SNP309 status and breast cancer risk were demonstrated in non-Chinese populations. In conclusion, the association between MDM2 SNP309 and breast cancer is modified by race. MDM2 SNP309 represents a risk factor for breast cancer in Chinese women but not in non-Chinese women. This phenomenon is analogous to that described in the context of lung cancer.